target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id A3 receptor,21,P0DMS8,Human,"(R,S)-PHPNECA",369,,91827339,CCNC(=O)[C@H]1O[C@H]([C@H]([C@H]1O)O)n1cnc2c1nc(C#CC(c1ccccc1)O)nc2N,"InChI=1S/C21H22N6O5/c1-2-23-20(31)17-15(29)16(30)21(32-17)27-10-24-14-18(22)25-13(26-19(14)27)9-8-12(28)11-6-4-3-5-7-11/h3-7,10,12,15-17,21,28-30H,2H2,1H3,(H,23,31)(H2,22,25,26)/t12?,15-,16+,17+,21-/m1/s1",WOAZCBPWCCREDO-CERUIEQFSA-N,Agonist,Full agonist,,,,,pKi,,9.4,,,,,,,,,,12109910, A3 receptor,21,P28647,Rat,2-chloroadenosine,372,,8974,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2N,"InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1",BIXYYZIIJIXVFW-UUOKFMHZSA-N,Agonist,Agonist,,,,,pKi,,5.72,,Ki,,1890.0,,=,,,,8022403, A3 receptor,21,P0DMS8,Human,2-hexynyl-NECA,373,,164437,CCCCC#Cc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)C(=O)NCC,"InChI=1S/C18H24N6O4/c1-3-5-6-7-8-10-22-15(19)11-16(23-10)24(9-21-11)18-13(26)12(25)14(28-18)17(27)20-4-2/h9,12-14,18,25-26H,3-6H2,1-2H3,(H,20,27)(H2,19,22,23)/t12-,13+,14-,18+/m0/s1",FDEACFAXFCKCHZ-MOROJQBDSA-N,Agonist,Full agonist,,,,,pKi,,8.6,,,,,,,,,,12109910, A3 receptor,21,P28647,Rat,CCPA,374,,123807,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1",XSMYYYQVWPZWIZ-IDTAVKCVSA-N,Agonist,Agonist,,,,,pKi,,6.63,,Ki,,237.0,,=,,,,, A3 receptor,21,P0DMS8,Human,CCPA,374,,123807,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1",XSMYYYQVWPZWIZ-IDTAVKCVSA-N,Agonist,Full agonist,,,,,pKi,,7.4,,,,,,=,,,,9459566|16518376, A3 receptor,21,P28647,Rat,CGS 21680,375,,3086599,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N,"InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1",PAOANWZGLPPROA-RQXXJAGISA-N,Agonist,Agonist,,,,,pKi,,6.23,,Ki,,584.0,,=,,,,, A3 receptor,21,P0DMS8,Human,CGS 21680,375,,3086599,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(NCCc1ccc(cc1)CCC(=O)O)nc2N,"InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)/t16-,17+,18-,22+/m0/s1",PAOANWZGLPPROA-RQXXJAGISA-N,Agonist,Full agonist,,,,,pKi,7.2,,6.0,,,,,=,,,,15476669|9459566|10779381|15267242|16518376, A3 receptor,21,P0DMS8,Human,NECA,377,,448222,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1",JADDQZYHOWSFJD-FLNNQWSLSA-N,Agonist,Full agonist,,,,,pKi,8.4,,7.5,,,,,=,,,,8234299|15476669|10779381|15267242|9364471|14662005, A3 receptor,21,P28647,Rat,NECA,377,,448222,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1",JADDQZYHOWSFJD-FLNNQWSLSA-N,Agonist,Full agonist,,,,,pKi,6.9,,6.6,,,,,=,,,,7929142, A3 receptor,21,P0DMS8,Human,PENECA,378,,9953255,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(C#Cc1ccccc1)nc2N,"InChI=1S/C20H20N6O4/c1-2-22-19(29)16-14(27)15(28)20(30-16)26-10-23-13-17(21)24-12(25-18(13)26)9-8-11-6-4-3-5-7-11/h3-7,10,14-16,20,27-28H,2H2,1H3,(H,22,29)(H2,21,24,25)/t14-,15+,16-,20+/m0/s1",SWXXHYTUMIMRFO-KSVNGYGVSA-N,Agonist,Full agonist,,,,,pKi,,8.2,,,,,,,,,,12109910, A3 receptor,21,P0DMS8,Human,cyclopentyladenosine,380,,657378,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCC1,"InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1",SQMWSBKSHWARHU-SDBHATRESA-N,Agonist,Full agonist,,,,,pKi,7.4,,7.0,,,,,=,,,,8234299|15476669|9459566|16518376, A3 receptor,21,P0DMS8,Human,CGS 15943,384,,2690,Clc1ccc2c(c1)c1nc(nn1c(n2)N)c1ccco1,"InChI=1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)",MSJODEOZODDVGW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.9,,7.0,,,,,=,,,,9459566|9933143|10779381|8863790, A3 receptor,21,P0DMS8,Human,DPCPX,386,,1329,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)",FFBDFADSZUINTG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,6.61,,5.4,Ki,3960.0,,243.0,=,,,,8234299|9459566|10779381|16902942|11906291|9351976, A3 receptor,21,P28647,Rat,DPCPX,386,,1329,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C1CCCC1,"InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)",FFBDFADSZUINTG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.6,,4.37,Ki,,,,=,,,,7929142|16902942|9351976, A3 receptor,21,P0DMS8,Human,MRE 2029F20,390,,135484064,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1cc(nn1C)OCC(=O)Nc1ccc2c(c1)OCO2,"InChI=1S/C24H27N7O6/c1-4-8-30-22-20(23(33)31(9-5-2)24(30)34)26-21(27-22)15-11-19(28-29(15)3)35-12-18(32)25-14-6-7-16-17(10-14)37-13-36-16/h6-7,10-11H,4-5,8-9,12-13H2,1-3H3,(H,25,32)(H,26,27)",DBWQRFKXNBVPGA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,14998332, A3 receptor,21,P0DMS8,Human,MRS1041,392,,10247549,CCOc1cc(OCC)c2c(c1)oc(c(c2=O)OCC)c1ccccc1,"InChI=1S/C21H22O5/c1-4-23-15-12-16(24-5-2)18-17(13-15)26-20(14-10-8-7-9-11-14)21(19(18)22)25-6-3/h7-13H,4-6H2,1-3H3",YMQQPRDUZIXHBJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.4,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,MRS1042,393,,10500941,CCCOc1cc(OCCC)c2c(c1)oc(c(c2=O)OCCC)c1ccccc1,"InChI=1S/C24H28O5/c1-4-12-26-18-15-19(27-13-5-2)21-20(16-18)29-23(17-10-8-7-9-11-17)24(22(21)25)28-14-6-3/h7-11,15-16H,4-6,12-14H2,1-3H3",ABZJCSJCNNCZRY-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.5,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,MRS1093,399,,10568125,CCOc1cc(O)c2c(c1)oc(c(c2=O)OCC)c1ccccc1,"InChI=1S/C19H18O5/c1-3-22-13-10-14(20)16-15(11-13)24-18(12-8-6-5-7-9-12)19(17(16)21)23-4-2/h5-11,20H,3-4H2,1-2H3",ZPEWNDIPSPULBP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.1,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,MRS928,402,,117900,COc1cc(OC)c2c(c1)oc(c(c2=O)OC)c1ccccc1,"InChI=1S/C18H16O5/c1-20-12-9-13(21-2)15-14(10-12)23-17(18(22-3)16(15)19)11-7-5-4-6-8-11/h4-10H,1-3H3",CBTHKWVPSIGKMI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.9,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,SCH 58261,403,,176408,Nc1nc2n(CCc3ccccc3)ncc2c2n1nc(n2)c1ccco1,"InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)",UTLPKQYUXOEJIL-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.92,,Ki,,1200.0,,=,,,,16518376, A3 receptor,21,P0DMS8,Human,xanthine amine congener,404,,5697,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN,"InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)",FIQGIOAELHTLHM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,7.4,,7.0,,,,,=,,,,8234299|9459566|10779381, A3 receptor,21,P28647,Rat,xanthine amine congener,404,,5697,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)NCCN,"InChI=1S/C21H28N6O4/c1-3-11-26-19-17(20(29)27(12-4-2)21(26)30)24-18(25-19)14-5-7-15(8-6-14)31-13-16(28)23-10-9-22/h5-8H,3-4,9-13,22H2,1-2H3,(H,23,28)(H,24,25)",FIQGIOAELHTLHM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,,,,,7929142, A3 receptor,21,P0DMS8,Human,ZM-241385,405,,176407,Oc1ccc(cc1)CCNc1nc(N)n2c(n1)nc(n2)c1ccco1,"InChI=1S/C16H15N7O2/c17-14-20-15(18-8-7-10-3-5-11(24)6-4-10)21-16-19-13(22-23(14)16)12-2-1-9-25-12/h1-6,9,24H,7-8H2,(H3,17,18,19,20,21,22)",PWTBZOIUWZOPFT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.13,,Ki,,743.0,,=,,,,16518376, A3 receptor,21,P0DMS8,Human,caffeine,407,,2519,Cn1cnc2c1c(=O)n(C)c(=O)n2C,"InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3",RYYVLZVUVIJVGH-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,4.88,,Ki,,13300.0,,=,,,,, A3 receptor,21,P28647,Rat,caffeine,407,,2519,Cn1cnc2c1c(=O)n(C)c(=O)n2C,"InChI=1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3",RYYVLZVUVIJVGH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.0,,Ki,,100000.0,,>,,,,19569717, A3 receptor,21,P0DMS8,Human,flavanone,408,,10251,O=C1CC(Oc2c1cccc2)c1ccccc1,"InChI=1S/C15H12O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-9,15H,10H2",ZONYXWQDUYMKFB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.3,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,flavone,409,,10680,O=c1cc(oc2c1cccc2)c1ccccc1,InChI=1S/C15H10O2/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,VHBFFQKBGNRLFZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.8,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,galangin,410,,5281616,Oc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccccc1,"InChI=1S/C15H10O5/c16-9-6-10(17)12-11(7-9)20-15(14(19)13(12)18)8-4-2-1-3-5-8/h1-7,16-17,19H",VCCRNZQBSJXYJD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.5,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,sakuranetin,412,,73571,COc1cc2O[C@@H](CC(=O)c2c(c1)O)c1ccc(cc1)O,"InChI=1S/C16H14O5/c1-20-11-6-12(18)16-13(19)8-14(21-15(16)7-11)9-2-4-10(17)5-3-9/h2-7,14,17-18H,8H2,1H3/t14-/m0/s1",DJOJDHGQRNZXQQ-AWEZNQCLSA-N,Antagonist,Antagonist,,,,,pKi,,5.5,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,theophylline,413,,2153,Cn1c(=O)n(C)c2c(c1=O)[nH]cn2,"InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)",ZFXYFBGIUFBOJW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,4.65,,4.06,Ki,86400.0,,22300.0,=,,,,9459566, A3 receptor,21,P28647,Rat,theophylline,413,,2153,Cn1c(=O)n(C)c2c(c1=O)[nH]cn2,"InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)",ZFXYFBGIUFBOJW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,4.07,,4.0,Ki,100000.0,,85000.0,=,,,,8022403|7632796, A3 receptor,21,P0DMS8,Human,(R)-PIA,414,,93205,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1",RIRGCFBBHQEQQH-SSFGXONLSA-N,Agonist,Full agonist,,,,,pKi,8.1,,7.1,,,,,=,,,,8234299|15476669|9459566|10779381|9364471, A3 receptor,21,P28647,Rat,(R)-PIA,414,,93205,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13-,15-,16-,19-/m1/s1",RIRGCFBBHQEQQH-SSFGXONLSA-N,Agonist,Full agonist,,,,,pKi,6.8,,6.6,,,,,=,,,,7929142|8441759, A3 receptor,21,P0DMS8,Human,(S)-PIA,415,,5312112,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N[C@H](Cc1ccccc1)C,"InChI=1S/C19H23N5O4/c1-11(7-12-5-3-2-4-6-12)23-17-14-18(21-9-20-17)24(10-22-14)19-16(27)15(26)13(8-25)28-19/h2-6,9-11,13,15-16,19,25-27H,7-8H2,1H3,(H,20,21,23)/t11-,13+,15+,16+,19+/m0/s1",RIRGCFBBHQEQQH-KFAHYOAQSA-N,Agonist,Full agonist,,,,,pKi,7.4,,6.3,,,,,,,,,8234299|9459566|10779381, A3 receptor,21,P0DMS8,Human,AB-MECA,416,,5310992,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(cc1)N,"InChI=1S/C18H21N7O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-2-4-10(19)5-3-9/h2-5,7-8,12-14,18,26-27H,6,19H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1",LDYMCRRFCMRFKB-MOROJQBDSA-N,Agonist,Full agonist,,,,,pKi,,7.7,,,,,,,,,,9459566|10779381, A3 receptor,21,P0DMS8,Human,piclidenoson,422,,123683,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1)I,"InChI=1S/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1",HUJXGQILHAUCCV-MOROJQBDSA-N,Agonist,Full agonist,,,,,pKi,9.2,,8.7,,,,,=,,,,9459566|10779381|11705449|8126704, A3 receptor,21,P0DMS8,Human,N(6)-cyclohexyladenosine,423,,9841284,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1,"InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1",SZBULDQSDUXAPJ-XNIJJKJLSA-N,Agonist,Agonist,,,,,pKi,,5.99,,Ki,,1025.0,,=,,,,8617970, A3 receptor,21,P28647,Rat,N(6)-cyclohexyladenosine,423,,9841284,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NC1CCCCC1,"InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1",SZBULDQSDUXAPJ-XNIJJKJLSA-N,Agonist,Agonist,,,,,pKi,,6.75,,Ki,,176.0,,=,,,,8022403, A3 receptor,21,P0DMS8,Human,[3H]NECA,425,,448222,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1",JADDQZYHOWSFJD-FLNNQWSLSA-N,Agonist,Full agonist,,,,,pKd,8.2,,7.9,,,,,,,,,9459566|11705449, A3 receptor,21,P0DMS8,Human,MRS1088,429,,252696,Clc1ccc2c(c1)c(=O)c(c(o2)c1ccccc1)Cl,InChI=1S/C15H8Cl2O2/c16-10-6-7-12-11(8-10)14(18)13(17)15(19-12)9-4-2-1-3-5-9/h1-8H,PTNKLWUWHUGKTA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.1,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,visnagin,433,,6716,COc1c2c(=O)cc(oc2cc2c1cco2)C,"InChI=1S/C13H10O4/c1-7-5-9(14)12-11(17-7)6-10-8(3-4-16-10)13(12)15-2/h3-6H,1-2H3",NZVQLVGOZRELTG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,4.2,,,,,,,,,,8691424, A3 receptor,21,P0DMS8,Human,[125I]AB-MECA,436,,73754993,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(c(c1)[125I])N,"InChI=1S/C18H20IN7O4/c1-21-17(29)14-12(27)13(28)18(30-14)26-7-25-11-15(23-6-24-16(11)26)22-5-8-2-3-10(20)9(19)4-8/h2-4,6-7,12-14,18,27-28H,5,20H2,1H3,(H,21,29)(H,22,23,24)/t12-,13+,14-,18+/m0/s1/i19-2",LOGOEBMHHXYBID-WBKNRDRNSA-N,Agonist,Full agonist,,,,,pKd,9.1,,9.0,Kd,1.0,,0.6,=,,,,9933143|10779381, A3 receptor,21,P28647,Rat,[125I]AB-MECA,436,,73754993,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(c(c1)[125I])N,"InChI=1S/C18H20IN7O4/c1-21-17(29)14-12(27)13(28)18(30-14)26-7-25-11-15(23-6-24-16(11)26)22-5-8-2-3-10(20)9(19)4-8/h2-4,6-7,12-14,18,27-28H,5,20H2,1H3,(H,21,29)(H,22,23,24)/t12-,13+,14-,18+/m0/s1/i19-2",LOGOEBMHHXYBID-WBKNRDRNSA-N,Agonist,Full agonist,,,,,pKd,,8.9,,,,,,=,,,,7929142, A3 receptor,21,P0DMS8,Human,BW-A1433,443,,6439089,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O,"InChI=1S/C20H22N4O4/c1-3-11-23-18-16(19(27)24(12-4-2)20(23)28)21-17(22-18)14-8-5-13(6-9-14)7-10-15(25)26/h5-10H,3-4,11-12H2,1-2H3,(H,21,22)(H,25,26)/b10-7+",UGCOFEOEBHUEHA-JXMROGBWSA-N,Antagonist,Antagonist,,,,,pKi,,7.3,,,,,,,,,,8234299, A3 receptor,21,P28647,Rat,BW-A1433,443,,6439089,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)/C=C/C(=O)O,"InChI=1S/C20H22N4O4/c1-3-11-23-18-16(19(27)24(12-4-2)20(23)28)21-17(22-18)14-8-5-13(6-9-14)7-10-15(25)26/h5-10H,3-4,11-12H2,1-2H3,(H,21,22)(H,25,26)/b10-7+",UGCOFEOEBHUEHA-JXMROGBWSA-N,Antagonist,Antagonist,,,,,pKi,,7.4,,,,,,,,,,7929142, A3 receptor,21,P0DMS8,Human,I-ABOPX,446,,163889,CCCn1c(=O)c2[nH]c(nc2n(c1=O)Cc1ccc(c(c1)I)N)c1ccc(cc1)OCC(=O)O,"InChI=1S/C23H22IN5O5/c1-2-9-28-22(32)19-21(29(23(28)33)11-13-3-8-17(25)16(24)10-13)27-20(26-19)14-4-6-15(7-5-14)34-12-18(30)31/h3-8,10H,2,9,11-12,25H2,1H3,(H,26,27)(H,30,31)",DKJMGIXWGPEEFF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,,,,,8234299, A3 receptor,21,P0DMS8,Human,MRS1220,448,,393595,O=C(Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl)Cc1ccccc1,"InChI=1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28)",TWWFAXQOKNBUCR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.2,,8.2,Ki,6.31,,0.63,=,,,,9364471|8863790|16553647|11226132, A3 receptor,21,P0DMS8,Human,MRS1754,449,,6603931,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)c1ccc(cc1)OCC(=O)Nc1ccc(cc1)C#N,"InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)",AJBBEYXFRYFVNM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.24,,Ki,,570.0,,=,,,,10737749, A3 receptor,21,Q61618,Mouse,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Agonist,,,,,pKi,,9.74,,Ki,,0.18,,=,,,,, A3 receptor,21,P28647,Rat,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Agonist,,,,,pKi,,9.48,,Ki,,0.33,,=,,,,, A3 receptor,21,P0DMS8,Human,Cl-IB-MECA,457,,3035850,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)I,"InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1",IPSYPUKKXMNCNQ-PFHKOEEOSA-N,Agonist,Full agonist,,,,,pKi,8.9,,8.0,,,,,=,,,,10731034|9364471|7932588, A3 receptor,21,P0DMS8,Human,I-ABA,458,,125348,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(c(c1)I)N,"InChI=1S/C17H19IN6O4/c18-9-3-8(1-2-10(9)19)4-20-15-12-16(22-6-21-15)24(7-23-12)17-14(27)13(26)11(5-25)28-17/h1-3,6-7,11,13-14,17,25-27H,4-5,19H2,(H,20,21,22)/t11-,13-,14-,17-/m1/s1",REGZQZHKIFOMRK-LSCFUAHRSA-N,Agonist,Full agonist,,,,,pKi,,8.0,,,,,,,,,,8234299, A3 receptor,21,P0DMS8,Human,MRE 3008F20,459,,5310960,CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC,"InChI=1S/C21H20N8O3/c1-3-10-28-12-15-17(26-28)24-20(25-21(30)22-13-6-8-14(31-2)9-7-13)29-19(15)23-18(27-29)16-5-4-11-32-16/h4-9,11-12H,3,10H2,1-2H3,(H2,22,24,25,26,30)",CJRNHKSLHHWUAB-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKi,,8.0,,,,,,,,,,10779381, A3 receptor,21,P0DMS8,Human,MRE 3008F20,459,,5310960,CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC,"InChI=1S/C21H20N8O3/c1-3-10-28-12-15-17(26-28)24-20(25-21(30)22-13-6-8-14(31-2)9-7-13)29-19(15)23-18(27-29)16-5-4-11-32-16/h4-9,11-12H,3,10H2,1-2H3,(H2,22,24,25,26,30)",CJRNHKSLHHWUAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,9.5,,9.0,,,,,=,,,,16219300|10779381|16518376, A3 receptor,21,P0DMS8,Human,MPC-MECA,460,,10432715,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1ccc(cc1)OC,"InChI=1S/C20H24N6O5/c1-3-21-19(29)16-14(27)15(28)20(31-16)26-10-25-13-17(23-9-24-18(13)26)22-8-11-4-6-12(30-2)7-5-11/h4-7,9-10,14-16,20,27-28H,3,8H2,1-2H3,(H,21,29)(H,22,23,24)/t14-,15+,16-,20+/m0/s1",BNXGNSTUSRFBCI-KSVNGYGVSA-N,Agonist,Full agonist,,,,,pKi,,6.8,,,,,,,,,,10779381, A3 receptor,21,P0DMS8,Human,[125I]APNEA,462,,4397,OCC1OC(C(C1O)O)n1cnc2c1ncnc2NCCc1ccc(cc1)N,"InChI=1S/C18H22N6O4/c19-11-3-1-10(2-4-11)5-6-20-16-13-17(22-8-21-16)24(9-23-13)18-15(27)14(26)12(7-25)28-18/h1-4,8-9,12,14-15,18,25-27H,5-7,19H2,(H,20,21,22)",XTPOZVLRZZIEBW-UHFFFAOYSA-N,Agonist,Full agonist,,,,,pKd,,7.8,,,,,,,,,,1323836, A3 receptor,21,P0DMS8,Human,dexniguldipine,463,,6918097,COC(=O)C1=C(C)NC(=C([C@@H]1c1cccc(c1)[N+](=O)[O-])C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1)C,"InChI=1S/C36H39N3O6/c1-25-31(34(40)44-3)33(27-12-10-17-30(24-27)39(42)43)32(26(2)37-25)35(41)45-23-11-20-38-21-18-36(19-22-38,28-13-6-4-7-14-28)29-15-8-5-9-16-29/h4-10,12-17,24,33,37H,11,18-23H2,1-3H3/t33-/m1/s1",SVJMLYUFVDMUHP-MGBGTMOVSA-N,Antagonist,Antagonist,,,,,pKi,,5.7,,,,,,,,,,8709132, A3 receptor,21,P0DMS8,Human,MRE 3010F20,465,,73754994,CCCn1cc2c(n1)N=C(C1C2=NC(=N1)C1CCCO1)NC(=O)Nc1cccc(c1)Cl,"InChI=1S/C21H22ClN7O2/c1-2-8-29-11-14-16-17(25-19(24-16)15-7-4-9-31-15)20(26-18(14)28-29)27-21(30)23-13-6-3-5-12(22)10-13/h3,5-6,10-11,15,17H,2,4,7-9H2,1H3,(H2,23,26,27,28,30)",AQJYVSDITBKWSI-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.3,,,,,,=,,,,10779381, A3 receptor,21,P0DMS8,Human,MRS1067,466,,252716,CC(Oc1cc(C)ccc1c1oc2ccc(cc2c(=O)c1Cl)Cl)C,"InChI=1S/C19H16Cl2O3/c1-10(2)23-16-8-11(3)4-6-13(16)19-17(21)18(22)14-9-12(20)5-7-15(14)24-19/h4-10H,1-3H3",PWGZOUCWGRTPSM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.2,,,,,,,,,,8691424|9364471, A3 receptor,21,P0DMS8,Human,MRS1097,467,,9953766,CCOC(=O)C1=C(C)NC(=C(C1/C=C/c1ccccc1)C(=O)OCC)c1ccccc1,"InChI=1S/C26H27NO4/c1-4-30-25(28)22-18(3)27-24(20-14-10-7-11-15-20)23(26(29)31-5-2)21(22)17-16-19-12-8-6-9-13-19/h6-17,21,27H,4-5H2,1-3H3/b17-16+",XCXCNPNUEPMYRS-WUKNDPDISA-N,Antagonist,Antagonist,,,,,pKi,,7.0,,,,,,,,,,9364471|8709132, A3 receptor,21,P0DMS8,Human,MRS1177,468,,10045876,Clc1ccc2c(c1)c1nc(nn1c(n2)NC(=O)c1ccccc1)c1ccco1,"InChI=1S/C20H12ClN5O2/c21-13-8-9-15-14(11-13)18-23-17(16-7-4-10-28-16)25-26(18)20(22-15)24-19(27)12-5-2-1-3-6-12/h1-11H,(H,22,24,27)",XIEBLXLGWFCYEP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.5,,,,,,,,,,8863790, A3 receptor,21,P0DMS8,Human,MRS1186,469,,10065929,CCC(=O)Nc1nc2ccc(cc2c2n1nc(n2)c1ccco1)Cl,"InChI=1S/C16H12ClN5O2/c1-2-13(23)19-16-18-11-6-5-9(17)8-10(11)15-20-14(21-22(15)16)12-4-3-7-24-12/h3-8H,2H2,1H3,(H,18,19,23)",SPZIDRYLSXDAEF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.1,,,,,,,,,,8863790, A3 receptor,21,P0DMS8,Human,MRS1191,470,,393594,CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1,"InChI=1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3",SNVFDPHQAOXWJZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.5,,,,,,=,,,,9364471|8917655, A3 receptor,21,P28647,Rat,MRS1191,470,,393594,CCOC(=O)C1=C(C)NC(=C(C1C#Cc1ccccc1)C(=O)OCc1ccccc1)c1ccccc1,"InChI=1S/C31H27NO4/c1-3-35-30(33)27-22(2)32-29(25-17-11-6-12-18-25)28(26(27)20-19-23-13-7-4-8-14-23)31(34)36-21-24-15-9-5-10-16-24/h4-18,26,32H,3,21H2,1-2H3",SNVFDPHQAOXWJZ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.8,,,,,,=,,,,9703464, A3 receptor,21,P0DMS8,Human,MRS1476,471,,9885773,CCOC(=O)c1c(nc(c(c1CC)C(=O)SCC)CC)c1ccccc1,"InChI=1S/C21H25NO3S/c1-5-15-17(21(24)26-8-4)16(6-2)22-19(14-12-10-9-11-13-14)18(15)20(23)25-7-3/h9-13H,5-8H2,1-4H3",WYZGZKCWULQWSH-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,,,,,=,,,,9703464, A3 receptor,21,P0DMS8,Human,MRS1486,472,,9843120,CCOC(=O)c1c(CC)c(C(=O)SCC)c(nc1c1ccccc1)CCC,"InChI=1S/C22H27NO3S/c1-5-12-17-18(22(25)27-8-4)16(6-2)19(21(24)26-7-3)20(23-17)15-13-10-9-11-14-15/h9-11,13-14H,5-8,12H2,1-4H3",GSMBGLUYORHXJR-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.5,,,,,,,,,,9703464, A3 receptor,21,P0DMS8,Human,MRS1505,473,,9802941,CCCOC(=O)c1c(nc(c(c1CC)C(=O)SCCC)CC)c1cccc(c1)Cl,"InChI=1S/C23H28ClNO3S/c1-5-12-28-22(26)20-17(7-3)19(23(27)29-13-6-2)18(8-4)25-21(20)15-10-9-11-16(24)14-15/h9-11,14H,5-8,12-13H2,1-4H3",RPTCJTNYKDJGHU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.1,,,,,,,,,,9703464, A3 receptor,21,P0DMS8,Human,MRS1523,474,,3661570,CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC,"InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3",UUSHFEVEROROSP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.7,,Ki,,19.9,,=,,,,9703464, A3 receptor,21,Q61618,Mouse,MRS1523,474,,3661570,CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC,"InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3",UUSHFEVEROROSP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.14,,Ki,,731.0,,=,,,,, A3 receptor,21,P28647,Rat,MRS1523,474,,3661570,CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(nc1c1ccccc1)CC,"InChI=1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3",UUSHFEVEROROSP-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.95,,Ki,,113.0,,=,,,,, A3 receptor,21,P0DMS8,Human,VUF8504,475,,10832101,COc1ccc(cc1)C(=O)Nc1nc(nc2c1cccc2)c1ccccn1,"InChI=1S/C21H16N4O2/c1-27-15-11-9-14(10-12-15)21(26)25-19-16-6-2-3-7-17(16)23-20(24-19)18-8-4-5-13-22-18/h2-13H,1H3,(H,23,24,25,26)",TTYULORVZLXLQA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,7.8,,,,,,,,,,9767637, A3 receptor,21,P0DMS8,Human,VUF8507,476,,10448986,O=C(c1ccccc1)Nc1nc(cc2c1cccc2)c1ccccn1,"InChI=1S/C21H15N3O/c25-21(15-8-2-1-3-9-15)24-20-17-11-5-4-10-16(17)14-19(23-20)18-12-6-7-13-22-18/h1-14H,(H,23,24,25)",FWRPUFITEHOETQ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.7,,,,,,,,,,9767637, A3 receptor,21,P0DMS8,Human,[3H]MRE 3008F20,477,,5310960,CCCn1cc2c(n1)nc(n1c2nc(n1)c1ccco1)NC(=O)Nc1ccc(cc1)OC,"InChI=1S/C21H20N8O3/c1-3-10-28-12-15-17(26-28)24-20(25-21(30)22-13-6-8-14(31-2)9-7-13)29-19(15)23-18(27-29)16-5-4-11-32-16/h4-9,11-12H,3,10H2,1-2H3,(H2,22,24,25,26,30)",CJRNHKSLHHWUAB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,9.1,,,,,,,,,,10779381|10698437, A3 receptor,21,P0DMS8,Human,nicardipine,2559,,4474,COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C,"InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3",ZBBHBTPTTSWHBA-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.5,,,,,,,,,,8709132, A3 receptor,21,P0DMS8,Human,adenosine,2844,,60961,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1",OIRDTQYFTABQOQ-KQYNXXCUSA-N,Agonist,Agonist,,yes,,,pKi,,6.54,,Ki,,290.0,,=,,,,15822182|7746802|14662005, A3 receptor,21,P28647,Rat,adenosine,2844,,60961,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N,"InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6-,7-,10-/m1/s1",OIRDTQYFTABQOQ-KQYNXXCUSA-N,Agonist,Agonist,,yes,,,pKi,,5.19,,Ki,,6500.0,,=,,,,14662005, A3 receptor,21,P0DMS8,Human,VUF5574,3280,,4046493,COc1ccccc1NC(=O)Nc1nc(nc2c1cccc2)c1cccnc1,"InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)",YRAFEJSZTVWUMD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,8.39,,Ki,,4.03,,=,,,,10841801, A3 receptor,21,P0DMS8,Human,derenofylline,3281,,9953065,O[C@@H]1CC[C@H](CC1)Nc1nc(nc2c1cc[nH]2)c1ccccc1,"InChI=1S/C18H20N4O/c23-14-8-6-13(7-9-14)20-18-15-10-11-19-17(15)21-16(22-18)12-4-2-1-3-5-12/h1-5,10-11,13-14,23H,6-9H2,(H2,19,20,21,22)/t13-,14-",RBZNJGHIKXAKQE-HDJSIYSDSA-N,Antagonist,Antagonist,,,,,pKi,,6.7,,Ki,,200.0,,=,,,,17558436, A3 receptor,21,P0DMS8,Human,SCH442416,3283,,10668061,COc1ccc(cc1)CCCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1,"InChI=1S/C20H19N7O2/c1-28-14-8-6-13(7-9-14)4-2-10-26-18-15(12-22-26)19-23-17(16-5-3-11-29-16)25-27(19)20(21)24-18/h3,5-9,11-12H,2,4,10H2,1H3,(H2,21,24)",AEULVFLPCJOBCE-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,16518376, A3 receptor,21,P0DMS8,Human,PSB603,3284,,44185871,CCCn1c(=O)[nH]c2c(c1=O)[nH]c(n2)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)Cl,"InChI=1S/C24H25ClN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33)",OVHCTHHFOHMNFV-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,19569717, A3 receptor,21,P0DMS8,Human,PSB36,3285,,11689583,OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3,"InChI=1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23)",CIBIXJYFYPFMTN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.64,,Ki,,2300.0,,=,,,,16902942, A3 receptor,21,P28647,Rat,PSB36,3285,,11689583,OCCCn1c2[nH]c(nc2c(=O)n(c1=O)CCCC)C12CC3CC2CC(C1)C3,"InChI=1S/C21H30N4O3/c1-2-3-5-25-18(27)16-17(24(20(25)28)6-4-7-26)23-19(22-16)21-11-13-8-14(12-21)10-15(21)9-13/h13-15,26H,2-12H2,1H3,(H,22,23)",CIBIXJYFYPFMTN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.19,,Ki,,6500.0,,=,,,,16902942, A3 receptor,21,P0DMS8,Human,PSB1115,3286,,5311479,CCCn1c(=O)[nH]c2c(c1=O)nc([nH]2)c1ccc(cc1)S(=O)(=O)O,"InChI=1S/C14H14N4O5S/c1-2-7-18-13(19)10-12(17-14(18)20)16-11(15-10)8-3-5-9(6-4-8)24(21,22)23/h3-6H,2,7H2,1H3,(H,15,16)(H,17,20)(H,21,22,23)",UYDRRQPGDSIMNU-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,11906291, A3 receptor,21,P0DMS8,Human,BAY 60-6583,3289,,11717831,N#Cc1c(N)nc(c(c1c1ccc(cc1)OCC1CC1)C#N)SCC(=O)N,"InChI=1S/C19H17N5O2S/c20-7-14-17(12-3-5-13(6-4-12)26-9-11-1-2-11)15(8-21)19(24-18(14)23)27-10-16(22)25/h3-6,11H,1-2,9-10H2,(H2,22,25)(H2,23,24)",ZTYHZMAZUWOXNC-UHFFFAOYSA-N,Agonist,Agonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,17632123, A3 receptor,21,P0DMS8,Human,apadenoson,3290,,9805430,CCNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(C#CC[C@@H]1CC[C@H](CC1)C(=O)OC)nc2N,"InChI=1S/C23H30N6O6/c1-3-25-21(32)18-16(30)17(31)22(35-18)29-11-26-15-19(24)27-14(28-20(15)29)6-4-5-12-7-9-13(10-8-12)23(33)34-2/h11-13,16-18,22,30-31H,3,5,7-10H2,1-2H3,(H,25,32)(H2,24,27,28)/t12-,13-,16-,17+,18-,22+/m0/s1",FLEVIENZILQUKB-XTWQNQIISA-N,Agonist,Agonist,,,,,pKi,,7.35,,Ki,,45.0,,=,,,,16518376, A3 receptor,21,P0DMS8,Human,TCPA,5590,,136218973,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=N/C(=O)Nc1ccccc1)nc2NC1CCCC1,"InChI=1S/C22H27N9O5/c32-10-14-16(33)17(34)20(36-14)31-11-23-15-18(24-12-8-4-5-9-12)26-21(27-19(15)31)28-30-29-22(35)25-13-6-2-1-3-7-13/h1-3,6-7,11-12,14,16-17,20,32-34H,4-5,8-10H2,(H3,24,25,26,27,28,29,35)/t14-,16-,17-,20-/m1/s1",RZJAODYQRFMAKN-WVSUBDOOSA-N,Agonist,Agonist,,,,,pKi,,6.22,,Ki,,600.0,,=,,,,12672250, A3 receptor,21,P28647,Rat,2'-Me-CCPA,5591,,10475082,OC[C@H]1O[C@H]([C@]([C@@H]1O)(C)O)n1cnc2c1nc(Cl)nc2NC1CCCC1,"InChI=1S/C16H22ClN5O4/c1-16(25)11(24)9(6-23)26-14(16)22-7-18-10-12(19-8-4-2-3-5-8)20-15(17)21-13(10)22/h7-9,11,14,23-25H,2-6H2,1H3,(H,19,20,21)/t9-,11-,14-,16-/m1/s1",MMPAUXMIDJWGFO-ROMFRFKVSA-N,Agonist,Agonist,,,,,pKi,,5.3,,Ki,,5000.0,,=,,,,9572897, A3 receptor,21,P0DMS8,Human,GS9667,5593,,11561692,O[C@@H]1[C@H](O)[C@H](O[C@H]1n1cnc2c1ncnc2N[C@@H]1CCC[C@H]1O)CSc1ccccc1F,"InChI=1S/C21H24FN5O4S/c22-11-4-1-2-7-15(11)32-8-14-17(29)18(30)21(31-14)27-10-25-16-19(23-9-24-20(16)27)26-12-5-3-6-13(12)28/h1-2,4,7,9-10,12-14,17-18,21,28-30H,3,5-6,8H2,(H,23,24,26)/t12-,13-,14-,17-,18-,21-/m1/s1",IZRXENCTXNMAMI-DIJFLQFKSA-N,Agonist,Agonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,19012505, A3 receptor,21,P0DMS8,Human,binodenoson,5595,,9576912,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(N/N=C/C1CCCCC1)nc2N,"InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1",XJFMHMFFBSOEPR-DNZQAUTHSA-N,Agonist,Agonist,,,,,pKi,,6.04,,Ki,,903.0,,=,,,,16518376, A3 receptor,21,P0DMS8,Human,regadenoson,5596,,219024,OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(nc2N)n1ncc(c1)C(=O)NC,"InChI=1S/C15H18N8O5/c1-17-13(27)6-2-19-23(3-6)15-20-11(16)8-12(21-15)22(5-18-8)14-10(26)9(25)7(4-24)28-14/h2-3,5,7,9-10,14,24-26H,4H2,1H3,(H,17,27)(H2,16,20,21)/t7-,9-,10-,14-/m1/s1",LZPZPHGJDAGEJZ-AKAIJSEGSA-N,Agonist,Agonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,16518376, A3 receptor,21,P0DMS8,Human,"CP608,039",5598,,73977920,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1N)O)n1cnc2c1ncnc2NCc1cc(Cl)ccc1COc1onc(c1)C,"InChI=1S/C23H25ClN8O5/c1-11-5-15(37-31-11)35-8-12-3-4-14(24)6-13(12)7-27-20-17-21(29-9-28-20)32(10-30-17)23-18(33)16(25)19(36-23)22(34)26-2/h3-6,9-10,16,18-19,23,33H,7-8,25H2,1-2H3,(H,26,34)(H,27,28,29)/t16-,18+,19-,23+/m0/s1",KXDJDMIUJGBFAV-QYUDBREXSA-N,Agonist,Agonist,,,,,pKi,,8.24,,Ki,,5.8,,=,,,,12919933, A3 receptor,21,P0DMS8,Human,HEMADO,5599,,10981286,CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO,"InChI=1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1",KOCIMZNSNPOGOP-IWCJZZDYSA-N,Agonist,Agonist,,,,,pKi,,8.96,,Ki,,1.1,,=,,,,12109910|17126322, A3 receptor,21,P0DMS8,Human,2-phenylethylyl-adenosine derivative,5600,,44598833,CNC(=O)[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(C#Cc1ccccc1)nc2NC,"InChI=1S/C20H20N6O4/c1-21-17-13-18(25-12(24-17)9-8-11-6-4-3-5-7-11)26(10-23-13)20-15(28)14(27)16(30-20)19(29)22-2/h3-7,10,14-16,20,27-28H,1-2H3,(H,22,29)(H,21,24,25)/t14-,15+,16-,20+/m0/s1",PAFSPMXSTBOTSN-KSVNGYGVSA-N,Agonist,Agonist,,,,,pKi,,9.36,,Ki,,0.44,,=,,,,19839592, A3 receptor,21,P0DMS8,Human,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,9.54,,Ki,,0.29,,=,,,,16518376, A3 receptor,21,Q61618,Mouse,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,8.83,,Ki,,1.49,,=,,,,, A3 receptor,21,P28647,Rat,MRS3558,5601,,11248240,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1nc(Cl)nc2NCc1cccc(c1)Cl,"InChI=1S/C20H20Cl2N6O3/c1-23-18(31)20-6-11(20)13(14(29)15(20)30)28-8-25-12-16(26-19(22)27-17(12)28)24-7-9-3-2-4-10(21)5-9/h2-5,8,11,13-15,29-30H,6-7H2,1H3,(H,23,31)(H,24,26,27)/t11-,13-,14+,15+,20+/m1/s1",GAYWHRPOIWFKIF-DDDALXFXSA-N,Agonist,Agonist,,,,,pKi,,9.0,,Ki,,1.0,,=,,,,, A3 receptor,21,P0DMS8,Human,rolofylline,5604,,64627,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CC3CC2CC(C1)C3,"InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22)",PJBFVWGQFLYWCB-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.36,,Ki,,4390.0,,=,,,,17125264, A3 receptor,21,P0DMS8,Human,tonapofylline,5605,,216466,CCCn1c2nc([nH]c2c(=O)n(c1=O)CCC)C12CCC(CC1)(CC2)CCC(=O)O,"InChI=1S/C22H32N4O4/c1-3-13-25-17-16(18(29)26(14-4-2)20(25)30)23-19(24-17)22-10-7-21(8-11-22,9-12-22)6-5-15(27)28/h3-14H2,1-2H3,(H,23,24)(H,27,28)",ZWTVVWUOTJRXKM-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,17125264, A3 receptor,21,P0DMS8,Human,FK-453,5606,,6439091,OCC[C@H]1CCCCN1C(=O)/C=C/c1c(nn2c1cccc2)c1ccccc1,"InChI=1S/C23H25N3O2/c27-17-14-19-10-4-6-15-25(19)22(28)13-12-20-21-11-5-7-16-26(21)24-23(20)18-8-2-1-3-9-18/h1-3,5,7-9,11-13,16,19,27H,4,6,10,14-15,17H2/b13-12+/t19-/m1/s1",OPLOPFHUHFGKMJ-JXOMPUQVSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,=,,,,16518376, A3 receptor,21,P0DMS8,Human,LUF5981,5607,,16109435,C1CCC(CC1)c1nc2c([nH]1)nc(cc2c1ccccc1)c1ccccc1,"InChI=1S/C24H23N3/c1-4-10-17(11-5-1)20-16-21(18-12-6-2-7-13-18)25-24-22(20)26-23(27-24)19-14-8-3-9-15-19/h1-2,4-7,10-13,16,19H,3,8-9,14-15H2,(H,25,26,27)",DXBBMCIVYYJMJC-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.2,,Ki,,637.0,,=,,,,17300165, A3 receptor,21,P0DMS8,Human,istradefylline,5608,,5311037,COc1cc(/C=C/c2nc3c(n2C)c(=O)n(c(=O)n3CC)CC)ccc1OC,"InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+",IQVRBWUUXZMOPW-PKNBQFBNSA-N,Antagonist,Antagonist,,,,,pKi,,5.35,,Ki,,4470.0,,=,,,,21303899, A3 receptor,21,P28647,Rat,CSC,5609,,5353365,Clc1cccc(c1)/C=C/c1nc2c(n1C)c(=O)n(c(=O)n2C)C,"InChI=1S/C16H15ClN4O2/c1-19-12(8-7-10-5-4-6-11(17)9-10)18-14-13(19)15(22)21(3)16(23)20(14)2/h4-9H,1-3H3/b8-7+",WBWFIUAVMCNYPG-BQYQJAHWSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,8022403, A3 receptor,21,P0DMS8,Human,MSX-2,5610,,10046145,OCCCn1c(=O)n(CC#C)c(=O)c2c1nc(n2C)/C=C/c1cccc(c1)OC,"InChI=1S/C21H22N4O4/c1-4-11-25-20(27)18-19(24(21(25)28)12-6-13-26)22-17(23(18)2)10-9-15-7-5-8-16(14-15)29-3/h1,5,7-10,14,26H,6,11-13H2,2-3H3/b10-9+",FWLDDFYHEQMIGG-MDZDMXLPSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,10669571, A3 receptor,21,P0DMS8,Human,vipadenant,5612,,21874557,Nc1nc(c2ccco2)c2c(n1)n(nn2)Cc1ccc(c(c1)C)N,"InChI=1S/C16H15N7O/c1-9-7-10(4-5-11(9)17)8-23-15-14(21-22-23)13(19-16(18)20-15)12-3-2-6-24-12/h2-7H,8,17H2,1H3,(H2,18,19,20)",HQSBCDPYXDGTCL-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1005.0,,=,,,,19072055, A3 receptor,21,P0DMS8,Human,ST-1535,5613,,9860294,CCCCc1nc(N)c2c(n1)n(C)c(n2)n1nccn1,"InChI=1S/C12H16N8/c1-3-4-5-8-16-10(13)9-11(17-8)19(2)12(18-9)20-14-6-7-15-20/h6-7H,3-5H2,1-2H3,(H2,13,16,17)",CYYQMAWUIRPCNW-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,16250647, A3 receptor,21,P0DMS8,Human,preladenant,5614,,10117987,COCCOc1ccc(cc1)N1CCN(CC1)CCn1ncc2c1nc(N)n1c2nc(n1)c1ccco1,"InChI=1S/C25H29N9O3/c1-35-15-16-36-19-6-4-18(5-7-19)32-11-8-31(9-12-32)10-13-33-23-20(17-27-33)24-28-22(21-3-2-14-37-21)30-34(24)25(26)29-23/h2-7,14,17H,8-13,15-16H2,1H3,(H2,26,29)",DTYWJKSSUANMHD-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,18221214, A3 receptor,21,P0DMS8,Human,CVT-6883,5615,,11270783,CCCn1c(=O)c2nc([nH]c2n(c1=O)CC)c1cnn(c1)Cc1cccc(c1)C(F)(F)F,"InChI=1S/C21H21F3N6O2/c1-3-8-30-19(31)16-18(29(4-2)20(30)32)27-17(26-16)14-10-25-28(12-14)11-13-6-5-7-15(9-13)21(22,23)24/h5-7,9-10,12H,3-4,8,11H2,1-2H3,(H,26,27)",KOYXXLLNCXWUNF-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.97,,Ki,,1070.0,,=,,,,18321039, A3 receptor,21,P0DMS8,Human,ATL802,5616,,24780383,CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C,"InChI=1S/C24H22F3N7O3/c1-3-10-33-20-18(22(36)34(23(33)37)15-6-7-15)30-19(31-20)13-5-9-17(29-11-13)32(2)21(35)14-4-8-16(28-12-14)24(25,26)27/h4-5,8-9,11-12,15H,3,6-7,10H2,1-2H3,(H,30,31)",IKIXRBGOWUFFBN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,6.0,,Ki,,1000.0,,>,,,,10737749, A3 receptor,21,Q61618,Mouse,ATL802,5616,,24780383,CCCn1c2nc([nH]c2c(=O)n(c1=O)C1CC1)c1ccc(nc1)N(C(=O)c1ccc(nc1)C(F)(F)F)C,"InChI=1S/C24H22F3N7O3/c1-3-10-33-20-18(22(36)34(23(33)37)15-6-7-15)30-19(31-20)13-5-9-17(29-11-13)32(2)21(35)14-4-8-16(28-12-14)24(25,26)27/h4-5,8-9,11-12,15H,3,6-7,10H2,1-2H3,(H,30,31)",IKIXRBGOWUFFBN-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.0,,Ki,,10000.0,,>,,,,10737749, A3 receptor,21,P0DMS8,Human,LAS38096,5617,,11716665,n1ccc(nc1)c1cnc(nc1c1ccco1)Nc1cccnc1,"InChI=1S/C17H12N6O/c1-3-12(9-18-6-1)22-17-20-10-13(14-5-7-19-11-21-14)16(23-17)15-4-2-8-24-15/h1-11H,(H,20,22,23)",YRPIMMMBNUUYLG-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,5.98,,Ki,,1043.0,,=,,,,17469811|20137946, A3 receptor,21,P0DMS8,Human,KF26777,5618,,135409562,CCCn1c2nc([nH]c2c2=NCCn2c1=O)c1ccc(cc1)Br,"InChI=1S/C16H16BrN5O/c1-2-8-21-15-12(14-18-7-9-22(14)16(21)23)19-13(20-15)10-3-5-11(17)6-4-10/h3-6H,2,7-9H2,1H3,(H,19,20)",GYGNZJDWTHECQT-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKi,,9.7,,Ki,,0.2,,=,,,,12063073, A3 receptor,21,P0DMS8,Human,PSB-10,5619,,135401232,CC[C@H]1N=c2n(C1)c(=O)n(c1c2[nH]c(n1)c1cc(Cl)cc(c1Cl)Cl)C,"InChI=1S/C16H14Cl3N5O/c1-3-8-6-24-15(20-8)12-14(23(2)16(24)25)22-13(21-12)9-4-7(17)5-10(18)11(9)19/h4-5,8H,3,6H2,1-2H3,(H,21,22)/t8-/m1/s1",YYDHUJWLNPIBDS-MRVPVSSYSA-N,Antagonist,Antagonist,,,,,pKi,,9.36,,Ki,,0.441,,=,,,,12139454, A3 receptor,21,P0DMS8,Human,PSB-11,5620,,135433658,CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1,"InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)/t11-/m1/s1",RGDHRCXUMURWBJ-LLVKDONJSA-N,Antagonist,Antagonist,,,,,pKd,,8.31,,Kd,,4.9,,=,,,,11814828, A3 receptor,21,P0DMS8,Human,PSB-11,5620,,135433658,CC[C@@H]1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1,"InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)/t11-/m1/s1",RGDHRCXUMURWBJ-LLVKDONJSA-N,Antagonist,Antagonist,,,,,pKi,,8.63,,Ki,,2.34,,=,,,,12517430, A3 receptor,21,P0DMS8,Human,MRS5151,5622,,91827346,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1C#CCCCC(=O)O)Cl,"InChI=1S/C26H27ClN6O5/c1-28-25(38)26-10-16(26)20(21(36)22(26)37)33-13-32-19-23(30-12-31-24(19)33)29-11-14-6-5-8-17(27)15(14)7-3-2-4-9-18(34)35/h5-6,8,12-13,16,20-22,36-37H,2,4,9-11H2,1H3,(H,28,38)(H,34,35)(H,29,30,31)/t16-,20-,21+,22+,26+/m1/s1",CYQQUPOETXXUCK-CSTWGOEFSA-N,Agonist,Agonist,,,,,pKi,,8.62,,Ki,,2.38,,=,,,,18424135, A3 receptor,21,Q61618,Mouse,MRS5151,5622,,91827346,CNC(=O)[C@]12C[C@@H]2[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2NCc1cccc(c1C#CCCCC(=O)O)Cl,"InChI=1S/C26H27ClN6O5/c1-28-25(38)26-10-16(26)20(21(36)22(26)37)33-13-32-19-23(30-12-31-24(19)33)29-11-14-6-5-8-17(27)15(14)7-3-2-4-9-18(34)35/h5-6,8,12-13,16,20-22,36-37H,2,4,9-11H2,1H3,(H,28,38)(H,34,35)(H,29,30,31)/t16-,20-,21+,22+,26+/m1/s1",CYQQUPOETXXUCK-CSTWGOEFSA-N,Agonist,Agonist,,,,,pKi,,7.61,,Ki,,24.4,,=,,,,18424135, A3 receptor,21,P0DMS8,Human,[3H]PSB-11,5729,,135921139,CCC1Cn2c(=N1)c1[nH]c(nc1n(c2=O)C)c1ccccc1,"InChI=1S/C16H17N5O/c1-3-11-9-21-15(17-11)12-14(20(2)16(21)22)19-13(18-12)10-7-5-4-6-8-10/h4-8,11H,3,9H2,1-2H3,(H,18,19)",RGDHRCXUMURWBJ-UHFFFAOYSA-N,Antagonist,Antagonist,,,,,pKd,,8.3,,,,,,=,,,,11814828, A3 receptor,21,P0DMS8,Human,[3H]HEMADO,5736,,10981286,CCCCC#Cc1nc(NC)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)CO,"InChI=1S/C17H23N5O4/c1-3-4-5-6-7-11-20-15(18-2)12-16(21-11)22(9-19-12)17-14(25)13(24)10(8-23)26-17/h9-10,13-14,17,23-25H,3-5,8H2,1-2H3,(H,18,20,21)/t10-,13-,14-,17-/m1/s1",KOCIMZNSNPOGOP-IWCJZZDYSA-N,Agonist,Full agonist,,,,,pKd,,9.0,,,,,,=,,,,17126322, A3 receptor,21,P0DMS8,Human,MRS5698,8421,,57523213,CNC(=O)[C@@]12C[C@@H]1[C@H]([C@@H]([C@@H]2O)O)n1cnc2c1nc(C#Cc1ccc(c(c1)F)F)nc2NCc1cccc(c1)Cl,"InChI=1S/C28H23ClF2N6O3/c1-32-27(40)28-11-17(28)22(23(38)24(28)39)37-13-34-21-25(33-12-15-3-2-4-16(29)9-15)35-20(36-26(21)37)8-6-14-5-7-18(30)19(31)10-14/h2-5,7,9-10,13,17,22-24,38-39H,11-12H2,1H3,(H,32,40)(H,33,35,36)/t17-,22-,23+,24+,28+/m1/s1",LYLLLJJYBWLGHW-CIZVZKTGSA-N,Agonist,Agonist,,,,,pKi,,8.5,,,,,,=,,,,22559880, A3 receptor,21,P0DMS8,Human,LUF6000,9446,,11711282,Clc1ccc(cc1Cl)Nc1nc2ccccc2c2c1[nH]c(n2)C1CCCCC1,"InChI=1S/C22H20Cl2N4/c23-16-11-10-14(12-17(16)24)25-22-20-19(15-8-4-5-9-18(15)26-22)27-21(28-20)13-6-2-1-3-7-13/h4-5,8-13H,1-3,6-7H2,(H,25,26)(H,27,28)",UWJVRSIGHHSDSJ-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,16722654, A3 receptor,21,P0DMS8,Human,LUF6096,9447,,25191023,O=C(C1CCCCC1)Nc1cc(Nc2ccc(c(c2)Cl)Cl)nc2c1cccc2,"InChI=1S/C22H21Cl2N3O/c23-17-11-10-15(12-18(17)24)25-21-13-20(16-8-4-5-9-19(16)26-21)27-22(28)14-6-2-1-3-7-14/h4-5,8-14H,1-3,6-7H2,(H2,25,26,27,28)",UWEIQVQNNLVOEI-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,19161279, A3 receptor,21,P0DMS8,Human,LUF7602,10351,,138393285,CCCn1c(=O)c2n3ccc(cc3nc2n(c1=O)CCCCNC(=O)c1ccc(cc1)S(=O)(=O)F)OC,"InChI=1S/C24H26FN5O6S/c1-3-12-30-23(32)20-21(27-19-15-17(36-2)10-14-28(19)20)29(24(30)33)13-5-4-11-26-22(31)16-6-8-18(9-7-16)37(25,34)35/h6-10,14-15H,3-5,11-13H2,1-2H3,(H,26,31)",WUZBOJXXYMKMMF-UHFFFAOYSA-N,Antagonist,Antagonist,,,yes,,pKi,,8.0,,Ki,,10.0,,=,"Displacement of [3H]PSB-11 binding from the hA3AR (in membranes from stably transfected CHO cells) following preincubation for 4 h,",,,30869893, A3 receptor,21,P0DMS8,Human,compound 6c [PMID: 34435786],11706,,156587569,O[C@H]1[C@@H](SC[C@H]1N)n1cnc2c(ncnc12)NC,"InChI=1S/C10H14N6OS/c1-12-8-6-9(14-3-13-8)16(4-15-6)10-7(17)5(11)2-18-10/h3-5,7,10,17H,2,11H2,1H3,(H,12,13,14)/t5-,7-,10-/m1/s1",MEYWNRDHEXYZIX-VISXPRAWSA-N,Agonist,Agonist,,,,,pKi,,8.62,,Ki,,2.4,,=,,,,34435786, A3 receptor,21,P0DMS8,Human,LJ-4517,12150,,164885960,O[C@H]1[C@@H](O)[C@H](n2c3nc(C#CCCCC)nc(N)c3nc2c2cccs2)OC1,"InChI=1S/C19H21N5O3S/c1-2-3-4-5-8-13-21-16(20)14-18(22-13)24(19-15(26)11(25)10-27-19)17(23-14)12-7-6-9-28-12/h6-7,9,11,15,19,25-26H,2-4,10H2,1H3,(H2,20,21,22)/t11-,15-,19-/m1/s1",MUHXGASCCALSAJ-PRIMNGNOSA-N,Antagonist,Antagonist,,,,,pKi,,7.81,,Ki,,15.6,,=,,,,35977382, A3 receptor,21,P0DMS8,Human,MRS8054,12483,,166176970,IC=1C=CC(=CC1)NC2=NC3=C(C4=C2N=C(C(CCC)CCC)N4)C=CC=C3,"InChI=1S/C23H25IN4/c1-3-7-15(8-4-2)22-27-20-18-9-5-6-10-19(18)26-23(21(20)28-22)25-17-13-11-16(24)12-14-17/h5-6,9-15H,3-4,7-8H2,1-2H3,(H,25,26)(H,27,28)",PMLCQIVFRJHHRF-UHFFFAOYSA-N,Allosteric modulator,Positive,,,,,,,,,,,,,=,,,,36367749,