target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id interleukin 1 receptor associated kinase 1,2042,P51617,Human,IRAK-1/4 inhibitor,5990,,11983295,O=C(c1cccc(c1)[N+](=O)[O-])Nc1nc2c(n1CCN1CCOCC1)cccc2,"InChI=1S/C20H21N5O4/c26-19(15-4-3-5-16(14-15)25(27)28)22-20-21-17-6-1-2-7-18(17)24(20)9-8-23-10-12-29-13-11-23/h1-7,14H,8-13H2,(H,21,22,26)",QTCFYQHZJIIHBS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,6.52,,IC50,,300.0,,=,,,,16563752, interleukin 1 receptor associated kinase 1,2042,P51617,Human,compound 1 [WO2012007375],8084,,58056241,NCC1CCN(CC1)c1ccc(cc1NC(=O)c1cnn2c1ncc(c2)O)Cl,"InChI=1S/C19H21ClN6O2/c20-13-1-2-17(25-5-3-12(8-21)4-6-25)16(7-13)24-19(28)15-10-23-26-11-14(27)9-22-18(15)26/h1-2,7,9-12,27H,3-6,8,21H2,(H,24,28)",BNVZRFQNZWYPQH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.26,,IC50,,55.0,,=,,,,, interleukin 1 receptor associated kinase 1,2042,P51617,Human,compound 7 [WO2012007375],8085,,58056092,NCCN(c1ncc2c(n1)c(cs2)C(=O)Nc1cc2cccnc2cc1OC)C,"InChI=1S/C20H20N6O2S/c1-26(7-5-21)20-23-10-17-18(25-20)13(11-29-17)19(27)24-15-8-12-4-3-6-22-14(12)9-16(15)28-2/h3-4,6,8-11H,5,7,21H2,1-2H3,(H,24,27)",BUJSZRICYLPWCM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.01,,IC50,,983.0,,=,,,,, interleukin 1 receptor associated kinase 1,2042,P51617,Human,Takinib,9655,,37750349,CCCn1/c(=N/C(=O)c2cccc(c2)C(=O)N)/[nH]c2c1cccc2,"InChI=1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24)",UOZVVPXKJGOFIG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.41,,IC50,,390.0,,=,,,,28820959, interleukin 1 receptor associated kinase 1,2042,P51617,Human,belizatinib,10474,,57345941,CC(NC(=O)C1CCC(CC1)n1c(NC(=O)c2ccc(cc2)F)nc2c1cc(cc2)CN1CCC(CC1)C(O)(C)C)C,"InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)",WSTUJEXAPHIEIM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,8.24,,Kd,,5.7,,=,Binding affinity in vitro.,,,22734674,