target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id TEK receptor tyrosine kinase,1842,Q02763,Human,linifanib,5657,,11485656,O=C(Nc1cc(C)ccc1F)Nc1ccc(cc1)c1cccc2c1c(N)n[nH]2,"InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)",MPVGZUGXCQEXTM-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.77,,IC50,,170.0,,=,,,,16648571, TEK receptor tyrosine kinase,1842,Q02763,Human,compound 8h [PMID: 21561767],8170,,46864270,OCCN1CCN(CC1)Cc1ccc(cc1C(F)(F)F)NC(=O)c1ccc(c(c1)C#Cc1cnc(n1C)C(=O)NC)C,"InChI=1S/C30H33F3N6O3/c1-20-4-5-22(16-21(20)7-9-25-18-35-27(37(25)3)29(42)34-2)28(41)36-24-8-6-23(26(17-24)30(31,32)33)19-39-12-10-38(11-13-39)14-15-40/h4-6,8,16-18,40H,10-15,19H2,1-3H3,(H,34,42)(H,36,41)",SUXYGJZMCWKJJI-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.66,,IC50,,2.2,,=,,,,21561767, TEK receptor tyrosine kinase,1842,Q02763,Human,CEP-11981,8189,,11751922,CC(Cn1c2ccc(cc2c2c1c1CCc3c(c1c1c2CNC1=O)cn(n3)C)Nc1ncccn1)C,"InChI=1S/C28H27N7O/c1-15(2)13-35-22-8-5-16(32-28-29-9-4-10-30-28)11-18(22)24-19-12-31-27(36)25(19)23-17(26(24)35)6-7-21-20(23)14-34(3)33-21/h4-5,8-11,14-15H,6-7,12-13H2,1-3H3,(H,31,36)(H,29,30,32)",AEULIVPVIDOLIN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.59,,IC50,,26.0,,=,,,,22148921, TEK receptor tyrosine kinase,1842,Q02763,Human,altiratinib,9174,,54576299,O=C(C1CC1)Nc1nccc(c1)Oc1cc(F)c(cc1F)NC(=O)C1(CC1)C(=O)Nc1ccc(cc1)F,"InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34)",GNNDEPIMDAZHRQ-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.62,,IC50,,2.4,,=,,,,, TEK receptor tyrosine kinase,1842,Q02763,Human,compound 5 [PMID: 17618114],9348,,23625762,COc1ccc2c(c1)ccc(c2)c1nc([nH]c1c1ccncc1)c1ccc(cc1)S(=O)C,"InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)",SINQIEAULQKUPD-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.6,,IC50,,250.0,,=,,,,17618114, TEK receptor tyrosine kinase,1842,Q02763,Human,merestinib,9841,,44603533,Fc1ccc(cc1)n1c(C)ccc(c1=O)C(=O)Nc1ccc(c(c1)F)Oc1cc2cnn(c2cc1c1c[nH]nc1)C,"InChI=1S/C30H22F2N6O3/c1-17-3-9-23(30(40)38(17)22-7-4-20(31)5-8-22)29(39)36-21-6-10-27(25(32)12-21)41-28-11-18-16-35-37(2)26(18)13-24(28)19-14-33-34-15-19/h3-16H,1-2H3,(H,33,34)(H,36,39)",QHADVLVFMKEIIP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.4,,IC50,,4.0,,=,Inhibition of in vitro biochemical activity by EMD Millipore assay.,,,23275061, TEK receptor tyrosine kinase,1842,Q02763,Human,compound 8i [PMID: 22765894],9905,,10433653,CCN1CCC(CC1)Nc1ccc2c(c1)/C(=C(/c1ncc([nH]1)C)\c1cccc(c1)F)/C(=O)N2,"InChI=1S/C26H28FN5O/c1-3-32-11-9-19(10-12-32)30-20-7-8-22-21(14-20)24(26(33)31-22)23(25-28-15-16(2)29-25)17-5-4-6-18(27)13-17/h4-8,13-15,19,30H,3,9-12H2,1-2H3,(H,28,29)(H,31,33)/b24-23-",DMQYDVBIPXAAJA-VHXPQNKSSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.57,,IC50,,270.0,,=,,,,21613405, TEK receptor tyrosine kinase,1842,Q02763,Human,pexmetinib,9917,,24765037,OCCn1ncc2c1ccc(c2)Oc1ccc(cc1CNC(=O)Nc1cc(nn1c1ccc(cc1)C)C(C)(C)C)F,"InChI=1S/C31H33FN6O3/c1-20-5-8-24(9-6-20)38-29(17-28(36-38)31(2,3)4)35-30(40)33-18-22-15-23(32)7-12-27(22)41-25-10-11-26-21(16-25)19-34-37(26)13-14-39/h5-12,15-17,19,39H,13-14,18H2,1-4H3,(H2,33,35,40)",LNMRSSIMGCDUTP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,9.0,,IC50,,1.0,,=,,,,27287719, TEK receptor tyrosine kinase,1842,Q02763,Human,DDR1/2 inhibitor 5n,10105,,134693894,CN1CCN(CC1)Cc1cc(NC(=O)c2ccc(c(c2)C#Cc2cnc3n2ccnc3)C(C)C)cc(c1)C(F)(F)F,"InChI=1S/C31H31F3N6O/c1-21(2)28-7-5-24(16-23(28)4-6-27-18-36-29-19-35-8-9-40(27)29)30(41)37-26-15-22(14-25(17-26)31(32,33)34)20-39-12-10-38(3)11-13-39/h5,7-9,14-19,21H,10-13,20H2,1-3H3,(H,37,41)",IUGBGEUCXVKGQK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pKd,,6.43,,Kd,,370.0,,=,,,,30075624,