target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id ribosomal protein S6 kinase A1,1527,Q15418,Human,dorsomorphin,4907,,11524144,C1CCN(CC1)CCOc1ccc(cc1)c1cnc2n(c1)ncc2c1ccncc1,"InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2",XHBVYDAKJHETMP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.68,,IC50,,210.0,,=,"Assayed using AMPK heterotrimeric complex containing α2, β1, γ1 subunits",,,20932747, ribosomal protein S6 kinase A1,1527,Q15418,Human,GSK-1838705A,5683,,25182616,CNC(=O)c1c(cccc1F)Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2c1cc[nH]2,"InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)",HZTYDQRUAWIZRE-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,5.8,,IC50,,1600.0,,=,,,,19825801, ribosomal protein S6 kinase A1,1527,Q15418,Human,BI-D1870,8038,,25023738,CC(CCN1C(C)C(=O)N(c2c1nc(nc2)Nc1cc(F)c(c(c1)F)O)C)C,"InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)",DTEKTGDVSARYDS-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.51,,IC50,,31.0,,=,,,,17040210, ribosomal protein S6 kinase A1,1527,Q15418,Human,compound 33 [PMID: 19364658],8163,,25207521,Oc1cccc(c1)C(C(=O)N)NC1=C(C(=O)C1=O)Nc1ccncc1,"InChI=1S/C17H14N4O4/c18-17(25)12(9-2-1-3-11(22)8-9)21-14-13(15(23)16(14)24)20-10-4-6-19-7-5-10/h1-8,12,21-22H,(H2,18,25)(H,19,20)",GPXKVULNYYNGDP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.54,,IC50,,290.0,,=,,,,19364658, ribosomal protein S6 kinase A1,1527,Q15418,Human,GSK429286A,9356,,11373846,O=C1NC(=C(C(C1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1cc2cn[nH]c2cc1F)C,"InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)",OLIIUAHHAZEXEX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.11,,IC50,,780.0,,=,,,,17201405, ribosomal protein S6 kinase A1,1527,Q15418,Human,prexasertib,9549,,46700756,NCCCOc1cccc(c1c1[nH]nc(c1)Nc1cnc(cn1)C#N)OC,"InChI=1S/C18H19N7O2/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25)",DOTGPNHGTYJDEP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,8.05,,IC50,,9.0,,=,Enzyme assay,,,26141948, ribosomal protein S6 kinase A1,1527,Q15418,Human,compound E22 [PMID: 31298542],10437,,138911338,CNC(=O)C[C@H]1NC[C@H]([C@@H](C1)c1ccc(c(c1)F)F)NC(=O)c1oc(c(c1)c1c(Cl)cnn1C)Cl,"InChI=1S/C23H23Cl2F2N5O3/c1-28-20(33)7-12-6-13(11-3-4-16(26)17(27)5-11)18(10-29-12)31-23(34)19-8-14(22(25)35-19)21-15(24)9-30-32(21)2/h3-5,8-9,12-13,18,29H,6-7,10H2,1-2H3,(H,28,33)(H,31,34)/t12-,13-,18+/m0/s1",SXDPQGRNHSLZPC-ZJNRKIDTSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.88,,IC50,,131.0,,=,,,,31298542,