target,target_id,target_uniprot,target_species,ligand,ligand_id,ligand_species,ligand_pubchem_cid,smiles,inchi,inchikey,type,action,action_comment,endogenous,primary_target,concentration_range,affinity_parameter,affinity_high,affinity_median,affinity_low,original_affinity_units,original_affinity_low_nm,original_affinity_median_nm,original_affinity_high_nm,original_affinity_relation,assay_description,receptor_site,ligand_context,pubmed_id Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,fasudil,5181,,3547,O=S(=O)(c1cccc2c1ccnc2)N1CCNCCC1,"InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2",NGOGFTYYXHNFQH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,5.57,,5.5,IC50,3160.0,,2670.0,=,,,,21145740|19597037, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,fasudil,5181,,3547,O=S(=O)(c1cccc2c1ccnc2)N1CCNCCC1,"InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2",NGOGFTYYXHNFQH-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKi,,7.0,,Ki,,100.0,,=,,,,21145740, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,Y27632,5290,,448042,C[C@H]([C@@H]1CC[C@H](CC1)C(=O)Nc1ccncc1)N,"InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1",IYOZTVGMEWJPKR-IJLUTSLNSA-N,Inhibitor,Inhibition,,,yes,,pIC50,7.34,,5.89,IC50,1290.0,,46.0,=,,,,20462760|19597037, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,Y27632,5290,,448042,C[C@H]([C@@H]1CC[C@H](CC1)C(=O)Nc1ccncc1)N,"InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1",IYOZTVGMEWJPKR-IJLUTSLNSA-N,Inhibitor,Inhibition,,,yes,,pKi,,6.85,,Ki,,140.0,,=,,,,9353125, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,GSK269962A,8037,,16095342,CCn1c(nc2c1cc(nc2)Oc1cccc(c1)NC(=O)c1ccc(cc1)OCCN1CCOCC1)c1nonc1N,"InChI=1S/C29H30N8O5/c1-2-37-24-17-25(31-18-23(24)33-28(37)26-27(30)35-42-34-26)41-22-5-3-4-20(16-22)32-29(38)19-6-8-21(9-7-19)40-15-12-36-10-13-39-14-11-36/h3-9,16-18H,2,10-15H2,1H3,(H2,30,35)(H,32,38)",YOVNFNXUCOWYSG-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.8,,IC50,,1.6,,=,In vitro inhibitory activity against recombinant ROCK1.,,,17018693, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,RKI-1447,8152,,60138149,O=C(Nc1scc(n1)c1ccncc1)NCc1cccc(c1)O,"InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)",GDVRVPIXWXOKQO-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,<,,,,23275831, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,compound 33 [PMID: 19364658],8163,,25207521,Oc1cccc(c1)C(C(=O)N)NC1=C(C(=O)C1=O)Nc1ccncc1,"InChI=1S/C17H14N4O4/c18-17(25)12(9-2-1-3-11(22)8-9)21-14-13(15(23)16(14)24)20-10-4-6-19-7-5-10/h1-8,12,21-22H,(H2,18,25)(H,19,20)",GPXKVULNYYNGDP-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.22,,IC50,,60.0,,=,,,,19364658, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,compound 22 [PMID: 20462760],8205,,24863112,O=C(C(c1ccccc1)NC1CC1)Nc1cc2cc[nH]c(=O)c2cc1Cl,"InChI=1S/C20H18ClN3O2/c21-16-11-15-13(8-9-22-19(15)25)10-17(16)24-20(26)18(23-14-6-7-14)12-4-2-1-3-5-12/h1-5,8-11,14,18,23H,6-7H2,(H,22,25)(H,24,26)",SKYALJGMRAGHEN-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.41,,IC50,,39.0,,=,,,,20462760, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,compound 35 [PMID: 20684608],8209,,46864283,COc1ccc2c(c1)C[C@@H](NC2)C(=O)Nc1ccc(cc1OCC1CCN(CC1)C)c1c[nH]nc1,"InChI=1S/C27H33N5O3/c1-32-9-7-18(8-10-32)17-35-26-13-19(22-15-29-30-16-22)4-6-24(26)31-27(33)25-12-21-11-23(34-2)5-3-20(21)14-28-25/h3-6,11,13,15-16,18,25,28H,7-10,12,14,17H2,1-2H3,(H,29,30)(H,31,33)/t25-/m1/s1",GFWDPXHTWJXOEI-RUZDIDTESA-N,Inhibitor,Inhibition,,,,,pIC50,,8.0,,IC50,,10.0,,=,,,,20684608, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,SAR407899,8910,,15604510,O=c1[nH]ccc2c1ccc(c2)OC1CCNCC1,"InChI=1S/C14H16N2O2/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11/h1-3,8-9,11,15H,4-7H2,(H,16,17)",IPEXHQGMTHOKQV-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,pIC50,,6.56,,IC50,,276.0,,=,,,,19597037, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,verosudil,8911,,66906051,CN(C(c1cscc1)C(=O)Nc1ccc2c(c1)cc[nH]c2=O)C,"InChI=1S/C17H17N3O2S/c1-20(2)15(12-6-8-23-10-12)17(22)19-13-3-4-14-11(9-13)5-7-18-16(14)21/h3-10,15H,1-2H3,(H,18,21)(H,19,22)",VDYRZXYYQMMFJW-UHFFFAOYSA-N,Inhibitor,Inhibition,,,,,,,,,,,,,=,,,,21794845, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,netarsudil,9322,,66599893,NC[C@@H](C(=O)Nc1ccc2c(c1)ccnc2)c1ccc(cc1)COC(=O)c1ccc(cc1C)C,"InChI=1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1",OURRXQUGYQRVML-AREMUKBSSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.49,,IC50,,32.6,,=,,,,31330446, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,GSK429286A,9356,,11373846,O=C1NC(=C(C(C1)c1ccc(cc1)C(F)(F)F)C(=O)Nc1cc2cn[nH]c2cc1F)C,"InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23,24)25/h2-6,8-9,14H,7H2,1H3,(H,26,29)(H,27,30)(H,28,31)",OLIIUAHHAZEXEX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.85,,IC50,,14.0,,=,,,,17201405, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,belumosudil,9558,,11950170,CC(NC(=O)COc1cccc(c1)c1nc(Nc2ccc3c(c2)cn[nH]3)c2c(n1)cccc2)C,"InChI=1S/C26H24N6O2/c1-16(2)28-24(33)15-34-20-7-5-6-17(13-20)25-30-23-9-4-3-8-21(23)26(31-25)29-19-10-11-22-18(12-19)14-27-32-22/h3-14,16H,15H2,1-2H3,(H,27,32)(H,28,33)(H,29,30,31)",GKHIVNAUVKXIIY-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,4.62,,IC50,,24000.0,,=,In a radiometric cell-free enzyme assay.,,,18832915, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,cortistatin A,9885,,11561907,CN([C@H]1C[C@@]23CC[C@@]4(O2)C(=CC[C@]2([C@H]4CC[C@@H]2c2ccc4c(c2)cncc4)C)C=C3[C@H]([C@@H]1O)O)C,"InChI=1S/C30H36N2O3/c1-28-10-8-21-15-23-26(33)27(34)24(32(2)3)16-29(23)11-12-30(21,35-29)25(28)7-6-22(28)19-5-4-18-9-13-31-17-20(18)14-19/h4-5,8-9,13-15,17,22,24-27,33-34H,6-7,10-12,16H2,1-3H3/t22-,24+,25-,26-,27-,28-,29-,30-/m1/s1",KSGZCKSNTAJOJS-DZBMUNJRSA-N,Inhibitor,Inhibition,,,,,pKd,,6.6,,Kd,,250.0,,=,,,,19844931, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,ripasudil,10423,,9863672,C[C@H]1CNCCCN1S(=O)(=O)c1cccc2c1c(F)cnc2,"InChI=1S/C15H18FN3O2S/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14/h2,4-5,9-11,17H,3,6-8H2,1H3/t11-/m0/s1",QSKQVZWVLOIIEV-NSHDSACASA-N,Inhibitor,Inhibition,,,yes,,pIC50,,7.29,,IC50,,51.0,,=,,,,24502505, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,HSD1590,10424,,139030519,COc1c(cccc1B(O)O)c1nc2ccc3c(c2c2c1CCC2)cn[nH]3,"InChI=1S/C20H18BN3O3/c1-27-20-13(6-3-7-15(20)21(25)26)19-12-5-2-4-11(12)18-14-10-22-24-16(14)8-9-17(18)23-19/h3,6-10,25-26H,2,4-5H2,1H3,(H,22,24)",WTZMCUOBQPTERK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.91,,IC50,,1.22,,=,,,,31330446, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,HSD1590,10424,,139030519,COc1c(cccc1B(O)O)c1nc2ccc3c(c2c2c1CCC2)cn[nH]3,"InChI=1S/C20H18BN3O3/c1-27-20-13(6-3-7-15(20)21(25)26)19-12-5-2-4-11(12)18-14-10-22-24-16(14)8-9-17(18)23-19/h3,6-10,25-26H,2,4-5H2,1H3,(H,22,24)",WTZMCUOBQPTERK-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pKd,,8.78,,Kd,,1.65,,=,,,,31330446, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,ROCK inhibitor 3,10425,,46182713,COc1nc(N[C@@H]2CC[C@H](CC2)N)c(cc1C(=O)N)F,"InChI=1S/C13H19FN4O2/c1-20-13-9(11(16)19)6-10(14)12(18-13)17-8-4-2-7(15)3-5-8/h6-8H,2-5,15H2,1H3,(H2,16,19)(H,17,18)/t7-,8-",IMZIJLMIOSQRGE-ZKCHVHJHSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,8.0,,IC50,,10.0,,=,,,,30753868, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,compound E22 [PMID: 31298542],10437,,138911338,CNC(=O)C[C@H]1NC[C@H]([C@@H](C1)c1ccc(c(c1)F)F)NC(=O)c1oc(c(c1)c1c(Cl)cnn1C)Cl,"InChI=1S/C23H23Cl2F2N5O3/c1-28-20(33)7-12-6-13(11-3-4-16(26)17(27)5-11)18(10-29-12)31-23(34)19-8-14(22(25)35-19)21-15(24)9-30-32(21)2/h3-5,8-9,12-13,18,29H,6-7,10H2,1-2H3,(H,28,33)(H,31,34)/t12-,13-,18+/m0/s1",SXDPQGRNHSLZPC-ZJNRKIDTSA-N,Inhibitor,Inhibition,,,,,pIC50,,7.19,,IC50,,64.0,,=,,,,31298542, Rho associated coiled-coil containing protein kinase 1,1503,Q13464,Human,compound 8 [PMID: 25898023],10498,,71283262,NCc1ccc(cc1c1cccc(c1)C(=O)Nc1ccc(cc1)C(=O)OC)C(=O)Nc1ccncc1F,"InChI=1S/C28H23FN4O4/c1-37-28(36)17-7-9-22(10-8-17)32-26(34)19-4-2-3-18(13-19)23-14-20(5-6-21(23)15-30)27(35)33-25-11-12-31-16-24(25)29/h2-14,16H,15,30H2,1H3,(H,32,34)(H,31,33,35)",MXWDBTLNBKIMEX-UHFFFAOYSA-N,Inhibitor,Inhibition,,,yes,,pIC50,,9.0,,IC50,,1.0,,<,Measured in a commercial radiometric kinase inhibition assay.,,,25898023,