Target has curated data in GtoImmuPdb
Contents:
- Gene and Protein Information
- Previous and Unofficial Names
- Database Links
- Natural/Endogenous Ligands
- Agonists
- Antagonists
- Immunopharmacology Comments
- Immuno Cell Type Associations
- Tissue Distribution
- Physiological Consequences of Altering Gene Expression
- Clinically-Relevant Mutations and Pathophysiology
- Biologically Significant Variants
- General Comments
- References
- Contributors
- How to cite this page
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 2 | 471 | 12q24.33 | P2RX2 | purinergic receptor P2X 2 | 18 |
| Mouse | 2 | 485 | 5 F | P2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 6 |
| Rat | 2 | 472 | 12q16 | P2rx2 | purinergic receptor P2X 2 | 2 |
| Previous and Unofficial Names |
| P2X purinoceptor 2 | purinergic receptor P2X, ligand gated ion channel, 2 | purinergic receptor P2X |
| Database Links |
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| Alphafold | Q9UBL9 (Hs), P49653 (Rn) |
| CATH/Gene3D | 2.60.490.10 |
| ChEMBL Target | CHEMBL2531 (Hs), CHEMBL2135 (Rn) |
| Ensembl Gene | ENSG00000187848 (Hs), ENSMUSG00000029503 (Mm), ENSRNOG00000037456 (Rn) |
| Entrez Gene | 22953 (Hs), 231602 (Mm), 114115 (Rn) |
| Human Protein Atlas | ENSG00000187848 (Hs) |
| KEGG Gene | hsa:22953 (Hs), mmu:231602 (Mm), rno:114115 (Rn) |
| OMIM | 600844 (Hs) |
| Orphanet | ORPHA330683 (Hs) |
| Pharos | Q9UBL9 (Hs) |
| RefSeq Nucleotide | NM_174873 (Hs), NM_170682 (Hs), NM_016318 (Hs), NM_170683 (Hs), NM_153400 (Mm), NM_053656 (Rn) |
| RefSeq Protein | NP_777362 (Hs), NP_057402 (Hs), NP_733782 (Hs), NP_733783 (Hs), NP_700449 (Mm), NP_446108 (Rn) |
| UniProtKB | Q9UBL9 (Hs), P49653 (Rn) |
| Wikipedia | P2RX2 (Hs) |
| Natural/Endogenous Ligands |
| ATP |
Download all structure-activity data for this target as a CSV file 
| Agonists | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||
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| Antagonists | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Immunopharmacology Comments |
| P2X ligand-gated ion channels elicit pro-inflammatory immune responses upon activation by extracellular ATP that acts as a DAMP when released from damaged or infected cells [3,5]. |
| Cell Type Associations | ||||||||
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| Tissue Distribution
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| Physiological Consequences of Altering Gene Expression
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| Clinically-Relevant Mutations and Pathophysiology
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| Biologically Significant Variants
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| General Comments |
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Although P2X2 is one of the most widely expressed P2X subunits in neurons, the complete knockout of P2X2 in mice produced relatively subtle effects [23]. These mice appear to display no overt CNS abnormalities, even though P2X2 is widely expressed in brain. Moreover, there are no examples of P2X2 receptor mediated fast ATP synaptic transmission in the brain. Overall, the function of P2X2 in brain requires further detailed evaluation. The human P2X2 subunit exists as 6 alternatively spliced isoforms (A, which is tabulated above; B, NP_777362 - 404 aa; C, NP_057402 - 447 aa; D, NP_733783 - 497 aa; H, NP_777361 - 379 aa and I, NP_057402 - 447 aa). |
References
1. Bo X, Alavi A, Xiang Z, Oglesby I, Ford A, Burnstock G. (1999) Localization of ATP-gated P2X2 and P2X3 receptor immunoreactive nerves in rat taste buds. Neuroreport, 10 (5): 1107-11. [PMID:10321492]
2. Brake AJ, Wagenbach MJ, Julius D. (1994) New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature, 371 (6497): 519-23. [PMID:7523952]
3. Burnstock G, Boeynaems JM. (2014) Purinergic signalling and immune cells. Purinergic Signal, 10 (4): 529-64. [PMID:25352330]
4. Castelucci P, Robbins HL, Poole DP, Furness JB. (2002) The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system. Histochem Cell Biol, 117 (5): 415-22. [PMID:12029488]
5. Cekic C, Linden J. (2016) Purinergic regulation of the immune system. Nat Rev Immunol, 16 (3): 177-92. [PMID:26922909]
6. Cockayne DA, Dunn PM, Zhong Y, Rong W, Hamilton SG, Knight GE, Ruan HZ, Ma B, Yip P, Nunn P, McMahon SB, Burnstock G, Ford AP. (2005) P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol (Lond.), 567 (Pt 2): 621-39. [PMID:15961431]
7. Collo G, North RA, Kawashima E, Merlo-Pich E, Neidhart S, Surprenant A, Buell G. (1996) Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci, 16 (8): 2495-507. [PMID:8786426]
8. Dowling P, Ranson RN, Santer RM. (2006) Age-associated changes in distribution of the P2X2 receptor in the major pelvic ganglion of the male rat. Neurosci Lett, 404 (3): 320-3. [PMID:16969922]
9. Housley GD, Kanjhan R, Raybould NP, Greenwood D, Salih SG, Järlebark L, Burton LD, Setz VC, Cannell MB, Soeller C et al.. (1999) Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission. J Neurosci, 19 (19): 8377-88. [PMID:10493739]
10. Jacobson KA, Ivanov AA, de Castro S, Harden TK, Ko H. (2009) Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal, 5 (1): 75-89. [PMID:18600475]
11. Jacobson KA, Jarvis MF, Williams M. (2002) Purine and pyrimidine (P2) receptors as drug targets. J Med Chem, 45 (19): 4057-93. [PMID:12213051]
12. Järlebark LE, Housley GD, Raybould NP, Vlajkovic S, Thorne PR. (2002) ATP-gated ion channels assembled from P2X2 receptor subunits in the mouse cochlea. Neuroreport, 13 (15): 1979-84. [PMID:12395104]
13. Järlebark LE, Housley GD, Thorne PR. (2000) Immunohistochemical localization of adenosine 5'-triphosphate-gated ion channel P2X(2) receptor subunits in adult and developing rat cochlea. J Comp Neurol, 421 (3): 289-301. [PMID:10813788]
14. Kaneda M, Ishii K, Morishima Y, Akagi T, Yamazaki Y, Nakanishi S, Hashikawa T. (2004) OFF-cholinergic-pathway-selective localization of P2X2 purinoceptors in the mouse retina. J Comp Neurol, 476 (1): 103-11. [PMID:15236470]
15. Kanjhan R, Housley GD, Burton LD, Christie DL, Kippenberger A, Thorne PR, Luo L, Ryan AF. (1999) Distribution of the P2X2 receptor subunit of the ATP-gated ion channels in the rat central nervous system. J Comp Neurol, 407 (1): 11-32. [PMID:10213185]
16. Khakh BS, Gittermann D, Cockayne DA, Jones A. (2003) ATP modulation of excitatory synapses onto interneurons. J Neurosci, 23 (19): 7426-37. [PMID:12917379]
17. Kobayashi K, Fukuoka T, Yamanaka H, Dai Y, Obata K, Tokunaga A, Noguchi K. (2005) Differential expression patterns of mRNAs for P2X receptor subunits in neurochemically characterized dorsal root ganglion neurons in the rat. J Comp Neurol, 481 (4): 377-90. [PMID:15593340]
18. Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF. (1999) Molecular and functional characterization of human P2X(2) receptors. Mol Pharmacol, 56 (6): 1171-81. [PMID:10570044]
19. Masin M, Kerschensteiner D, Dümke K, Rubio ME, Soto F. (2006) Fe65 interacts with P2X2 subunits at excitatory synapses and modulates receptor function. J Biol Chem, 281 (7): 4100-8. [PMID:16330549]
20. North RA, Jarvis MF. (2013) P2X receptors as drug targets. Mol Pharmacol, 83 (4): 759-69. [PMID:23253448]
21. Prasad M, Fearon IM, Zhang M, Laing M, Vollmer C, Nurse CA. (2001) Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling. J Physiol (Lond.), 537 (Pt 3): 667-77. [PMID:11744746]
22. Przybyła T, Sakowicz-Burkiewicz M, Pawełczyk T. (2018) Purinergic signaling in B cells. Acta Biochim Pol, 65 (1): 1-7. [PMID:29360885]
23. Ren J, Bian X, DeVries M, Schnegelsberg B, Cockayne DA, Ford AP, Galligan JJ. (2003) P2X2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol (Lond.), 552 (Pt 3): 809-21. [PMID:12937291]
24. Rong W, Gourine AV, Cockayne DA, Xiang Z, Ford AP, Spyer KM, Burnstock G. (2003) Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia. J Neurosci, 23 (36): 11315-21. [PMID:14672995]
25. Ruan HZ, Burnstock G. (2004) P2X2 and P2X3 receptor expression in the gallbladder of the guinea pig. Auton Neurosci, 111 (2): 89-96. [PMID:15182738]
26. Rubio ME, Soto F. (2001) Distinct Localization of P2X receptors at excitatory postsynaptic specializations. J Neurosci, 21 (2): 641-53. [PMID:11160443]
27. Simon J, Kidd EJ, Smith FM, Chessell IP, Murrell-Lagnado R, Humphrey PP, Barnard EA. (1997) Localization and functional expression of splice variants of the P2X2 receptor. Mol Pharmacol, 52 (2): 237-48. [PMID:9271346]
28. Staikopoulos V, Sessle BJ, Furness JB, Jennings EA. (2007) Localization of P2X2 and P2X3 receptors in rat trigeminal ganglion neurons. Neuroscience, 144 (1): 208-16. [PMID:17110047]
29. Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, Elde R. (1996) Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci USA, 93 (15): 8063-7. [PMID:8755603]
30. Vulchanova L, Riedl MS, Shuster SJ, Buell G, Surprenant A, North RA, Elde R. (1997) Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals. Neuropharmacology, 36 (9): 1229-42. [PMID:9364478]
31. Xiang Z, Bo X, Burnstock G. (1998) Localization of ATP-gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia. Neurosci Lett, 256 (2): 105-8. [PMID:9853714]
32. Xiang Z, Bo X, Burnstock G. (1999) P2X receptor immunoreactivity in the rat cochlea, vestibular ganglion and cochlear nucleus. Hear Res, 128 (1-2): 190-6. [PMID:10082298]
33. Xiang Z, Burnstock G. (2004) P2X2 and P2X3 purinoceptors in the rat enteric nervous system. Histochem Cell Biol, 121 (3): 169-79. [PMID:14767775]
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