Contents:
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 4 | 447 | 3q27.1 | HTR3C | 5-hydroxytryptamine receptor 3C | 3-5 |
| Previous and Unofficial Names |
| 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic |
| Database Links |
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| Alphafold | Q8WXA8 (Hs) |
| CATH/Gene3D | 2.70.170.10 |
| ChEMBL Target | CHEMBL4296091 (Hs) |
| Ensembl Gene | ENSG00000178084 (Hs) |
| Entrez Gene | 170572 (Hs) |
| Human Protein Atlas | ENSG00000178084 (Hs) |
| KEGG Gene | hsa:170572 (Hs) |
| OMIM | 610121 (Hs) |
| Pharos | Q8WXA8 (Hs) |
| RefSeq Nucleotide | NM_130770 (Hs) |
| RefSeq Protein | NP_570126 (Hs) |
| UniProtKB | Q8WXA8 (Hs) |
| Wikipedia | HTR3C (Hs) |
| Natural/Endogenous Ligands |
| 5-hydroxytryptamine |
| Tissue Distribution
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| Clinically-Relevant Mutations and Pathophysiology
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| General Comments |
| The HTR3C gene is absent from the rodent genome [2-4]. The human 5-HT3C subunit does not function as a homomer [2,5]. Co-expression with the 5-HT3A subunit has been found to mandatory for the expression of the 5-HT3C subunit at the cell surface in one study [5], but not in a second [2]. Co-assembly of the 5-HT3A and 5-HT3C subunits when heterologously expressed in HEK-293 cells has been demonstrated by immunoprecipitation [5]. Co-expression of the 5-HT3C and 5-HT3A subunits does not alter the potency of agonists and antagonists observed for homopentameric 5-HT3A receptors [2,5]. |
References
1. Fasching PA, Kollmannsberger B, Strissel PL, Niesler B, Engel J, Kreis H, Lux MP, Weihbrecht S, Lausen B, Bani MR, Beckmann MW, Strick R. (2008) Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. J Cancer Res Clin Oncol, 134 (10): 1079-86. [PMID:18389280]
2. Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP et al.. (2009) Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function. J Neurochem, 108 (2): 384-96. [PMID:19012743]
3. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW et al.. (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene, 319: 137-48. [PMID:14597179]
4. Niesler B, Frank B, Kapeller J, Rappold GA. (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene, 310: 101-11. [PMID:12801637]
5. Niesler B, Walstab J, Combrink S, Möller D, Kapeller J, Rietdorf J, Bönisch H, Göthert M, Rappold G, Brüss M. (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E. Mol Pharmacol, 72 (1): 8-17. [PMID:17392525]
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