Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	238	16q23.1	NUDT7	nudix hydrolase 7
Mouse	-	236	8 E1	Nudt7	nudix hydrolase 7
Rat	-	236	19q12	Nudt7	nudix hydrolase 7
Gene and Protein Information Comments
Alternatively spliced transcript variants which encode multiple isoforms have been found for the human, rat and mouse genes.

Previous and Unofficial Names

nudix (nucleoside diphosphate linked moiety X)-type motif 7

Database Links
Alphafold	P0C024 (Hs), Q99P30 (Mm)
BRENDA	3.6.1.-
Ensembl Gene	ENSG00000140876 (Hs), ENSMUSG00000031767 (Mm), ENSRNOG00000011976 (Rn)
Entrez Gene	283927 (Hs), 67528 (Mm), 361413 (Rn)
Human Protein Atlas	ENSG00000140876 (Hs)
KEGG Enzyme	3.6.1.-
KEGG Gene	hsa:283927 (Hs), mmu:67528 (Mm), rno:361413 (Rn)
OMIM	609231 (Hs)
Pharos	P0C024 (Hs)
RefSeq Nucleotide	NM_001105663 (Hs), NM_024437 (Mm), NM_001305426 (Rn)
RefSeq Protein	NP_001099133 (Hs), NP_077757 (Mm), NP_001292355 (Rn)
UniProtKB	P0C024 (Hs), Q99P30 (Mm)
Wikipedia	NUDT7 (Hs)

Enzyme Reaction
EC Number: 3.6.1.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference NUDT7-COV-1 Hs Inhibition 6.0 pIC50 4 ⤷ pIC50 6.0 (IC50 1.1x10-6 M) [4] Description: In an enzymatic assay monitoring NUDT7-induced acetyl-CoA hydrolysis; 30 minutes pre-incubation with inhibitor.

General Comments

Nudix hydrolase 7 (NUDT7) is one of a family of ~24 human genes that encode phosphohydrolase enzymes that share structural and functional properties. Nudix hydrolase activity is required for the removal of toxic nucleotide metabolites from cells, and for regulating the availability of important nucleotide substrates, cofactors (e.g. coenzyme A; CoA), and signalling molecules. The NUDT7 protein contains a CoA-binding motif and a C-terminal peroxisomal targeting signal and is expressed predominantly in the liver [1,3]. Through regulation of CoA, NUDT7 has been linked to metabolic and glucose homoeostasis and peroxisomal function [2]. Dysregulation of the NUDT7-PGAM1 axis has been implicated in pathologic cartilage-degradation in osteoarthritis [5].