Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	605	2q31.2	NFE2L2	NFE2 like bZIP transcription factor 2	2
Mouse	-	597	2 44.75 cM	Nfe2l2	nuclear factor, erythroid derived 2, like 2
Rat	-	604	3q23	Nfe2l2	NFE2 like bZIP transcription factor 2
Gene and Protein Information Comments
Multiple transcript variants encoding different isoforms have been characterized for the human gene.

Previous and Unofficial Names

nuclear factor, erythroid derived 2, like 2 | nuclear factor | NF-E2-related factor 2 | nuclear factor, erythroid 2-like 2

Database Links
Alphafold	Q16236 (Hs), Q60795 (Mm), O54968 (Rn)
ChEMBL Target	CHEMBL1075094 (Hs), CHEMBL1075148 (Mm), CHEMBL1075141 (Rn)
Ensembl Gene	ENSG00000116044 (Hs), ENSMUSG00000015839 (Mm), ENSRNOG00000001548 (Rn)
Entrez Gene	4780 (Hs), 18024 (Mm), 83619 (Rn)
Human Protein Atlas	ENSG00000116044 (Hs)
KEGG Gene	hsa:4780 (Hs), mmu:18024 (Mm), rno:83619 (Rn)
OMIM	600492 (Hs)
Pharos	Q16236 (Hs)
RefSeq Nucleotide	NM_006164 (Hs), NM_010902 (Mm), NM_031789 (Rn)
RefSeq Protein	NP_006155 (Hs), NP_035032 (Mm), NP_113977 (Rn)
UniProtKB	Q16236 (Hs), Q60795 (Mm), O54968 (Rn)
Wikipedia	NFE2L2 (Hs)

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference omaveloxolone Hs Activation - - 3-4 ⤷ [3-4]

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference ML385 Hs Binding - - 5 ⤷ [5]

Immunopharmacology Comments

NRF2 is included in GToImmuPdb as mutations in this gene have been reported in patients with IMDDHH, an inherited disease in which some of the symptoms arise from defective immune system function [1].

Immuno Process Associations

Immuno Process:  Cellular signalling

Immuno Process:  Cytokine production & signalling

Immuno Process:  Immune regulation

Immuno Process:  Immune system development

Immuno Process:  Inflammation

Immuno Disease Associations

Disease Name:  Immunodeficiency, developmental delay, and hypohomocysteinemia (IMDDHH) Disease Synonyms:  no synonynms Comment:  IMDDHH is associated with heterozygous missense mutations in the NFE2L2 gene. The mutations detected affect the N-terminal Neh2 domain of NRF2 that facilitates binding to inhibitory KEAP1 proteins (so KEAP1 inhibition of NRF2 is reduced), and this subsequently leads to chronic activation of NRF2-responsive stress response genes. Disease X-refs:  OMIM: 617744 References:  1

General Comments
NRF2 is a transcription factor that activates expression of genes containing the antioxidant response element (ARE). ARE-containing genes are involved in the physiological response to cellular insults such as oxidative stress.