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Hepatitis C virus genome polyprotein

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Target not currently curated in GtoImmuPdb

Target id: 2952

Nomenclature: Hepatitis C virus genome polyprotein

Systematic Nomenclature: Hepatitis C virus genome polyprotein

Family: Other viral proteins

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Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
simeprevir Small molecule or natural product Approved drug Primary target of this compound Ligand has a PDB structure HCV Inhibition 9.4 pKi 1
pKi 9.4 (Ki 3.6x10-10 M) [1]
General Comments
This polyprotein precursor is proteolytically processed inside the host cell to spawn a number of separate activities (see GO terms in UniProt entry) , including enzymes that are important for viral replication. Several of these are being persued as different anti-viral drug targets.


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1. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K et al.. (2008) Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg Med Chem Lett, 18 (17): 4853-8. [PMID:18678486]

How to cite this page

Other viral proteins: Hepatitis C virus genome polyprotein. Last modified on 31/03/2020. Accessed on 07/06/2023. IUPHAR/BPS Guide to PHARMACOLOGY,