pyrin and HIN domain family member 1 | Absent in melanoma (AIM)-like receptors (ALRs) | IUPHAR Guide to IMMUNOPHARMACOLOGY

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pyrin and HIN domain family member 1

  Target has curated data in GtoImmuPdb

Target id: 2925

Nomenclature: pyrin and HIN domain family member 1

Abbreviated Name: PYHIN1

Family: Absent in melanoma (AIM)-like receptors (ALRs)

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 492 1q23.1 PYHIN1 pyrin and HIN domain family member 1
Gene and Protein Information Comments
Alternative transcription of the human gene gives rise to several protein isoforms: alpha 1 (presented here), alpha 2, beta a and beta 2. There are no mouse or rat homologs of human PYHIN1 with 1:1 orthology.
Previous and Unofficial Names
IFIX i [2]
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Immunopharmacology Comments
PYHIN1 participates in the innate immune response to microbial DNA [1], and contributes to the induction of the interferon response to viral pathogens.
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 3 GO processes
GO:0032731 positive regulation of interleukin-1 beta production IBA
GO:0035457 cellular response to interferon-alpha IMP
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GO:0035458 cellular response to interferon-beta IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002218 activation of innate immune response IEA
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0002218 activation of innate immune response IEA
General Comments
PYHIN1 is a member of the ALR pattern recognition receptor family, a set of four related human genes classified by structural similarities as the Pyrin and HIN domain family (HGNC family 995). In addition to acting as a sensor of viral DNA, PYHIN1 also interacts with factors involved in transcriptional regulation and chromatin modulation [1].

References

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1. Diner BA, Li T, Greco TM, Crow MS, Fuesler JA, Wang J, Cristea IM. (2015) The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA. Mol. Syst. Biol., 11 (1): 787. [PMID:25665578]

2. Ding Y, Wang L, Su LK, Frey JA, Shao R, Hunt KK, Yan DH. (2004) Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer. Oncogene, 23 (26): 4556-66. [PMID:15122330]

How to cite this page

Absent in melanoma (AIM)-like receptors (ALRs): pyrin and HIN domain family member 1. Last modified on 20/03/2017. Accessed on 25/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2925.