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kallikrein related peptidase 14

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Target not currently curated in GtoImmuPdb

Target id: 2866

Nomenclature: kallikrein related peptidase 14

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 19q13.41 KLK14 kallikrein related peptidase 14
Mouse - 250 7 28.26 cM Klk14 kallikrein related-peptidase 14
Rat - - 1q22 Klk14 kallikrein related-peptidase 14
Previous and Unofficial Names Click here for help
kallikrein-related peptidase 14
Database Links Click here for help
Specialist databases
MEROPS S01.029 (Hs)
Other databases
Alphafold Q9P0G3 (Hs), Q8CGR5 (Mm)
ChEMBL Target CHEMBL2641 (Hs)
Ensembl Gene ENSG00000129437 (Hs), ENSMUSG00000044737 (Mm), ENSRNOG00000033706 (Rn)
Entrez Gene 43847 (Hs), 317653 (Mm), 308562 (Rn)
Human Protein Atlas ENSG00000129437 (Hs)
KEGG Gene hsa:43847 (Hs), mmu:317653 (Mm), rno:308562 (Rn)
OMIM 606135 (Hs)
Pharos Q9P0G3 (Hs)
RefSeq Nucleotide NM_022046 (Hs), NM_174866 (Mm)
RefSeq Protein NP_071329 (Hs), NP_777355 (Mm)
UniProtKB Q9P0G3 (Hs), Q8CGR5 (Mm)
Wikipedia KLK14 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 3 [PMID: 23849879] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.9 pIC50 1
⤷ pIC50 5.9 (IC50 1.29x10-6 M) [1]
compound 4d [PMID: 25489658] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 5.5 pIC50 2
⤷ pIC50 5.5 (IC50 2.9x10-6 M) [2]

References

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1. Tan X, Furio L, Reboud-Ravaux M, Villoutreix BO, Hovnanian A, El Amri C. (2013) 1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases. Bioorg Med Chem Lett, 23 (16): 4547-51. [PMID:23849879]

2. Tan X, Soualmia F, Furio L, Renard JF, Kempen I, Qin L, Pagano M, Pirotte B, El Amri C, Hovnanian A et al.. (2015) Toward the first class of suicide inhibitors of kallikreins involved in skin diseases. J Med Chem, 58 (2): 598-612. [PMID:25489658]

How to cite this page

S1: Chymotrypsin: kallikrein related peptidase 14. Last modified on 29/01/2016. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2866.