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egl-9 family hypoxia inducible factor 3

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Target not currently curated in GtoImmuPdb

Target id: 2834

Nomenclature: egl-9 family hypoxia inducible factor 3

Abbreviated Name: PHD3

Family: Prolyl hydroxylases

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 239 14q13.1 EGLN3 egl-9 family hypoxia inducible factor 3
Mouse - 239 12 C1 Egln3 egl-9 family hypoxia-inducible factor 3
Rat - 239 6q23 Egln3 egl-9 family hypoxia-inducible factor 3
Previous and Unofficial Names Click here for help
EGL nine (C.elegans) homolog 3 | HIF prolyl hydroxylase 3 | HIFPH3 | egl-9 family hypoxia-inducible factor 3
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 1.14.11.29

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 6ee [PMID: 22364528] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.5 pIC50 2
pIC50 8.5 (IC50 3.5x10-9 M) [2]
molidustat Small molecule or natural product Primary target of this compound Ligand has a PDB structure Hs Inhibition 6.3 pIC50 1
pIC50 6.3 (IC50 4.9x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling

References

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1. Thede K et al.. (2014) Substituted dihydropyrazolones for treating cardiovascular and hematological diseases. Patent number: US8653111 B2. Assignee: Bayer Intellectual Property Gmbh.. Priority date: 26/10/2006. Publication date: 18/02/2014.

2. Vachal P, Miao S, Pierce JM, Guiadeen D, Colandrea VJ, Wyvratt MJ, Salowe SP, Sonatore LM, Milligan JA, Hajdu R et al.. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. J Med Chem, 55 (7): 2945-59. [PMID:22364528]

How to cite this page

Prolyl hydroxylases: egl-9 family hypoxia inducible factor 3. Last modified on 17/07/2017. Accessed on 08/12/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2834.