Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	372	1p12	HSD3B2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Mouse	1	373	3 42.89 cM	Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Rat	-	373	2q34	Hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

Previous and Unofficial Names

3 beta-hydroxysteroid dehydrogenase/Delta 5 | Hsd3b2 | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 | hydroxy-delta-5-steroid dehydrogenase

Database Links
Alphafold	P26439 (Hs), P24815 (Mm)
BRENDA	1.1.1.145, 5.3.3.1
ChEMBL Target	CHEMBL3670 (Hs)
DrugBank Target	P26439 (Hs)
Ensembl Gene	ENSG00000203859 (Hs), ENSMUSG00000027871 (Mm), ENSRNOG00000070622 (Rn)
Entrez Gene	3284 (Hs), 15492 (Mm), 360348 (Rn)
Human Protein Atlas	ENSG00000203859 (Hs)
KEGG Enzyme	1.1.1.145, 5.3.3.1
KEGG Gene	hsa:3284 (Hs), mmu:15492 (Mm), rno:360348 (Rn)
OMIM	613890 (Hs)
Orphanet	ORPHA122515 (Hs)
Pharos	P26439 (Hs)
RefSeq Nucleotide	NM_000198 (Hs), NM_008293 (Mm), NM_001007719 (Rn)
RefSeq Protein	NP_000189 (Hs), NP_032319 (Mm), NP_001007720 (Rn)
UniProtKB	P26439 (Hs), P24815 (Mm)
Wikipedia	HSD3B2 (Hs)

Enzyme Reaction
EC Number: 1.1.1.145 EC Number: 5.3.3.1

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Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference trilostane N/A Inhibition 8.4 pIC50 1 ⤷ pIC50 8.4 (IC50 4x10-9 M) Note that the species is not specified in the referenced article. [1] Description: In vitro enzyme inhibition

Clinically-Relevant Mutations and Pathophysiology
Disease:  Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase type II deficiency Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255] Disease Ontology: DOID:12255 OMIM: 201810 Orphanet: ORPHA90791