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chymotrypsin C

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Target not currently curated in GtoImmuPdb

Target id: 2341

Nomenclature: chymotrypsin C

Family: S1: Chymotrypsin

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 268 1p36.21 CTRC chymotrypsin C
Mouse - 268 4 E1 Ctrc chymotrypsin C
Rat - 268 5q36 Ctrc chymotrypsin C
Previous and Unofficial Names Click here for help
CLCR | ELA4 | elastase 4 | serum calcium-decreasing factor | chymotrypsin C (caldecrin)
Database Links Click here for help
Specialist databases
MEROPS S01.157 (Hs)
Other databases
Alphafold Q99895 (Hs), Q3SYP2 (Mm), P55091 (Rn)
BRENDA 3.4.21.2
ChEMBL Target CHEMBL2386 (Hs)
Ensembl Gene ENSG00000162438 (Hs), ENSMUSG00000062478 (Mm), ENSRNOG00000013745 (Rn)
Entrez Gene 11330 (Hs), 76701 (Mm), 362653 (Rn)
Human Protein Atlas ENSG00000162438 (Hs)
KEGG Enzyme 3.4.21.2
KEGG Gene hsa:11330 (Hs), mmu:76701 (Mm), rno:362653 (Rn)
OMIM 601405 (Hs)
Orphanet ORPHA139109 (Hs)
Pharos Q99895 (Hs)
RefSeq Nucleotide NM_007272 (Hs), NM_001033875 (Mm), NM_001077649 (Rn)
RefSeq Protein NP_009203 (Hs), NP_001029047 (Mm), NP_001071117 (Rn)
UniProtKB Q99895 (Hs), Q3SYP2 (Mm), P55091 (Rn)
Wikipedia CTRC (Hs)
Enzyme Reaction Click here for help
EC Number: 3.4.21.2

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
milvexian Small molecule or natural product Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 7.5 pKi 2
⤷ pKi 7.5 (Ki 3.5x10-8 M) [2]
compound 20 [PMID: 12372533] Small molecule or natural product Hs Inhibition 7.3 pKi 4
⤷ pKi 7.3 (Ki 5x10-8 M) [4]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Hereditary pancreatitis
Synonyms: Hereditary chronic pancreatitis [Orphanet: ORPHA676]
OMIM: 167800
Orphanet: ORPHA676
Disease:  Tropical pancreatitis
Orphanet: ORPHA103918
References:  1,3

References

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1. Derikx MH, Szmola R, te Morsche RH, Sunderasan S, Chacko A, Drenth JP. (2009) Tropical calcific pancreatitis and its association with CTRC and SPINK1 (p.N34S) variants. Eur J Gastroenterol Hepatol, 21 (8): 889-94. [PMID:19404200]

2. Dilger AK, Pabbisetty KB, Corte JR, De Lucca I, Fang T, Yang W, Pinto DJP, Wang Y, Zhu Y, Mathur A et al.. (2022) Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy. J Med Chem, 65 (3): 1770-1785. [PMID:34494428]

3. Paliwal S, Bhaskar S, Mani KR, Reddy DN, Rao GV, Singh SP, Thomas V, Chandak GR. (2013) Comprehensive screening of chymotrypsin C (CTRC) gene in tropical calcific pancreatitis identifies novel variants. Gut, 62 (11): 1602-6. [PMID:22580415]

4. Priestley ES, De Lucca I, Ghavimi B, Erickson-Viitanen S, Decicco CP. (2002) P1 Phenethyl peptide boronic acid inhibitors of HCV NS3 protease. Bioorg Med Chem Lett, 12 (21): 3199-202. [PMID:12372533]

How to cite this page

S1: Chymotrypsin: chymotrypsin C. Last modified on 15/10/2021. Accessed on 16/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2341.