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sugen kinase 110

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Target not currently curated in GtoImmuPdb

Target id: 2290

Nomenclature: sugen kinase 110

Abbreviated Name: SGK110

Family: NKF1 family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 359 19q13.42 SBK3 SH3 domain binding kinase family member 3
Mouse - 361 7 A1 Sbk3 SH3 domain binding kinase family, member 3
Previous and Unofficial Names Click here for help
SG110 | Gm1078 | predicted gene 1078 | SH3 domain binding kinase family, member 3 | SH3 domain binding kinase family
Database Links Click here for help
Alphafold P0C264 (Hs), P0C5K0 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5116 (Hs)
Ensembl Gene ENSG00000231274 (Hs), ENSMUSG00000085272 (Mm)
Entrez Gene 100130827 (Hs), 381835 (Mm)
Human Protein Atlas ENSG00000231274 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:100130827 (Hs), mmu:381835 (Mm)
Pharos P0C264 (Hs)
RefSeq Nucleotide NM_001199824 (Hs), NM_001200041 (Mm)
RefSeq Protein NP_001186753 (Hs), NP_001186970 (Mm)
UniProtKB P0C264 (Hs), P0C5K0 (Mm)
Wikipedia SBK3 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound R-16 [PMID: 21967808] Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 2
⤷ [2]
Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
SGK110 activity is inhibited by 98% in the presence of 1μM compound R-16 [PMID 21967808] [2].
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: SgK110
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.3 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.9 pKd
tamatinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.7 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.6 pKd
crizotinib Small molecule or natural product Approved drug Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.6 pKd
tozasertib Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.3 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.0 pKd
JNJ-28312141 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 5.7 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Milkiewicz KL, Aimone LD, Albom MS, Angeles TS, Chang H, Grobelny JV, Husten J, Losardo C, Miknyoczki S, Murthy S et al.. (2011) Improvement in oral bioavailability of 2,4-diaminopyrimidine c-Met inhibitors by incorporation of a 3-amidobenzazepin-2-one group. Bioorg Med Chem, 19 (21): 6274-84. [PMID:21967808]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF1 family: sugen kinase 110. Last modified on 24/02/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2290.