Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	625	3p25.3	IRAK2	interleukin 1 receptor associated kinase 2
Mouse	-	622	6 52.82 cM	Irak2	interleukin-1 receptor-associated kinase 2
Rat	-	624	4q42	Irak2	interleukin-1 receptor-associated kinase 2

Previous and Unofficial Names

interleukin-1 receptor-associated kinase 2

Database Links
Alphafold	O43187 (Hs), Q8CFA1 (Mm), Q4QQS0 (Rn)
BRENDA	2.7.11.1
ChEMBL Target	CHEMBL4105759 (Hs)
Ensembl Gene	ENSG00000134070 (Hs), ENSMUSG00000060477 (Mm), ENSRNOG00000021817 (Rn)
Entrez Gene	3656 (Hs), 108960 (Mm), 362418 (Rn)
Human Protein Atlas	ENSG00000134070 (Hs)
KEGG Enzyme	2.7.11.1
KEGG Gene	hsa:3656 (Hs), mmu:108960 (Mm), rno:362418 (Rn)
OMIM	603304 (Hs)
Pharos	O43187 (Hs)
RefSeq Nucleotide	NM_001570 (Hs), NM_172161 (Mm), NM_001025422 (Rn)
RefSeq Protein	NP_001561 (Hs), NP_751893 (Mm), NP_001020593 (Rn)
UniProtKB	O43187 (Hs), Q8CFA1 (Mm), Q4QQS0 (Rn)
Wikipedia	IRAK2 (Hs)

Selected 3D Structures
	Description:  The ternary Death Domain complex of MyD88, IRAK4, and IRAK2 PDB Id:  3MOP Resolution:  3.4Å Species:  Human References:  1

Enzyme Reaction
EC Number: 2.7.11.1

Immunopharmacology Comments

IRAK2 is one of the proximal mediators of IL-1 signalling via the IL-1 receptor, the other being IRAK1. It plays a part in IL-1-induced upregulation of the transcription factor NF-κB. IRAK2 interacts with TRAF6 and Myd88.

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling

Immuno Process:  Cellular signalling