integrin linked kinase | ILK subfamily | IUPHAR Guide to IMMUNOPHARMACOLOGY

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integrin linked kinase

Target not currently curated in GtoImmuPdb

Target id: 2041

Nomenclature: integrin linked kinase

Abbreviated Name: ILK

Family: ILK subfamily

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 452 11p15.4 ILK integrin linked kinase
Mouse - 452 7 E1 Ilk integrin linked kinase
Rat - 452 1 q33 Ilk integrin-linked kinase
Previous and Unofficial Names
ILK1 | ILK2 | p59ILK | integrin-linked kinase
Database Links
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain
PDB Id:  3F6Q
Resolution:  1.6Å
Species:  Human
References:  1
Enzyme Reaction
EC Number: 2.7.11.1

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 22 [PMID: 21823616] Hs Inhibition 6.2 pIC50 2
pIC50 6.2 (IC50 6x10-7 M) [2]
Immuno Process Associations
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP

References

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1. Chiswell BP, Zhang R, Murphy JW, Boggon TJ, Calderwood DA. (2008) The structural basis of integrin-linked kinase-PINCH interactions. Proc. Natl. Acad. Sci. U.S.A., 105 (52): 20677-82. [PMID:19074270]

2. Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. (2011) Identification and characterization of a novel integrin-linked kinase inhibitor. J. Med. Chem., 54 (18): 6364-74. [PMID:21823616]

How to cite this page

ILK subfamily: integrin linked kinase. Last modified on 29/01/2016. Accessed on 23/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=2041.