Top ▲


Click here for help

Target not currently curated in GtoImmuPdb

Target id: 191

Nomenclature: ADGRF2

Family: Adhesion Class GPCRs

Gene and Protein Information Click here for help
Adhesion G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 708 6p12.3 ADGRF2 adhesion G protein-coupled receptor F2
Mouse 7 644 17 B3 Adgrf2 adhesion G protein-coupled receptor F2
Rat 7 650 9q12 Adgrf2 adhesion G protein-coupled receptor F2
Previous and Unofficial Names Click here for help
GPR111 (G protein-coupled receptor 111) | PGR20
Database Links Click here for help
Specialist databases
GPCRDB agrf2_human (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Agonist Comments
No ligands identified: orphan receptor.
Tissue Distribution Click here for help
Heart, skin, spleen, testis, brain, tongue, esophagus, forestomach
Species:  Mouse
Technique:  RT-PCR and LacZ insertion
References:  3
Expression Datasets Click here for help

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Physiological Functions Click here for help
Skin barrier assay
Species:  Mouse
Tissue:  Skin
References:  3
Physiological Consequences of Altering Gene Expression Comments
Adgrf2 knockout mice do not show defects in development or fertility [3].
General Comments
ADGRF2 (formerly GPR111) is an orphan receptor that belongs to Family VI Adhesion-GPCRs together with ADGRF1 and ADGRF3-5 [1]. The genes of Family VI Adhesion-GPCRs except ADGRF3 are syntenically clustered on human chromosome 6 and mouse chromosome 17 suggesting the evolution from an ancestral gene through gene duplication and exon shuffling [3].

Original gene prediction [2] failed to predict several exons at both the 5' and 3' ends and included one exon of ADGRF2 in the prediction of ADGRF4 which is the adjacent gene.

A rat cDNA similar to the mouse cDNA AK142836 can be predicted with an open reading frame of 650 amino acids.


Show »

1. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB. (2003) There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. Biochem Biophys Res Commun, 301 (3): 725-34. [PMID:12565841]

2. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB. (2002) Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. FEBS Lett, 531 (3): 407-14. [PMID:12435584]

3. Prömel S, Waller-Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MB, Grosse J, Schöneberg T, Russ AP et al.. (2012) Characterization and functional study of a cluster of four highly conserved orphan adhesion-GPCR in mouse. Dev Dyn, 241 (10): 1591-602. [PMID:22837050]


Show »

How to cite this page