Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	1	455	12p13.31	TNFRSF1A	TNF receptor superfamily member 1A
Mouse	1	454	6 59.32 cM	Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a
Rat	1	461	4q42	Tnfrsf1a	TNF receptor superfamily member 1A

Previous and Unofficial Names

CD120a | p55TNFR | TNFAR | TNF-R1 | TNF-R55 | tumor necrosis factor receptor superfamily, member 1A | tumor necrosis factor receptor superfamily

Database Links
Alphafold	P19438 (Hs), P25118 (Mm), P22934 (Rn)
ChEMBL Target	CHEMBL3378 (Hs)
Ensembl Gene	ENSG00000067182 (Hs), ENSMUSG00000030341 (Mm), ENSRNOG00000031312 (Rn)
Entrez Gene	7132 (Hs), 21937 (Mm), 25625 (Rn)
Human Protein Atlas	ENSG00000067182 (Hs)
KEGG Gene	hsa:7132 (Hs), mmu:21937 (Mm), rno:25625 (Rn)
OMIM	191190 (Hs)
Pharos	P19438 (Hs)
UniProtKB	P19438 (Hs), P25118 (Mm), P22934 (Rn)
Wikipedia	TNFRSF1A (Hs)

Natural/Endogenous Ligands
lymphotoxin-α {Sp: Human}
tumour necrosis factor membrane form {Sp: Human}
tumour necrosis factor shed form {Sp: Human}

Adaptor proteins (Human)

TRADD

Other Binding Ligands
Key to terms and symbols		Click column headers to sort
Ligand Sp. Action Value Parameter Reference lymphotoxin-α {Sp: Human} Hs - - - ⤷ tumour necrosis factor membrane form {Sp: Human} Hs - - - ⤷ tumour necrosis factor shed form {Sp: Human} Hs - - - ⤷

Immunopharmacology Comments

We have included TNFR1 in GtoImmuPdb based on it being a receptor for lymphotoxin-α, a cytotoxic protein performing a variety of important roles in immune system development and regulation [1-2].

Immuno Process Associations

Immuno Process:  Inflammation

Immuno Process:  Immune regulation

Immuno Process:  Cytokine production & signalling