Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	1093	11p15.4	NLRP14	NLR family pyrin domain containing 14
Mouse	-	993	7 E3	Nlrp14	NLR family, pyrin domain containing 14

Previous and Unofficial Names

CLR11.2 | GC-LRR | NALP14 | NOD5 | PAN8 | NACHT, leucine rich repeat and PYD containing 14 | NLR family, pyrin domain containing 14 | NLR family

Database Links
Alphafold	Q86W24 (Hs), Q6B966 (Mm)
Ensembl Gene	ENSG00000158077 (Hs), ENSMUSG00000016626 (Mm)
Entrez Gene	338323 (Hs), 76858 (Mm)
Human Protein Atlas	ENSG00000158077 (Hs)
KEGG Gene	hsa:338323 (Hs), mmu:76858 (Mm)
OMIM	609665 (Hs)
Pharos	Q86W24 (Hs)
UniProtKB	Q86W24 (Hs), Q6B966 (Mm)
Wikipedia	NLRP14 (Hs)

Immunopharmacology Comments

NLRP proteins are critical components of inflammasome complexes and are thereby involved in inflammasome-mediated activation of proinflammatory caspases. NLRP14 has the typical PYD-NACHT-LRR domain structure common to the NLRP protein family [1]. But despite this structural homology the biological function of NLRP14 is not as well defined as other similar proteins.

Tissue Distribution
NLRP14 is found exclusively in the testes: specifically expressed in spermatogonia, spermatocytes and spermatids Species:  Human Technique:  Northern blot, immunohistochemistry. References:  2

Physiological Functions
Spermatogenesis Species:  Human Tissue:  Spermatogonia, spermatocytes and spermatids. References:  2
Physiological Functions Comments
Involved in spermatogenesis

Clinically-Relevant Mutations and Pathophysiology
Disease:  Spermatogenic failure Description: A common cause of male subfertility (see PubMed ID 10522977). Resulting from various etiologies. Click column headers to sort Type Species Amino acid change Nucleotide change Description Reference Missense- premature STOP codon Human K108X Results in expression of a truncated protein which lacks the functional NACHT and LRR domains. 2