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MMP10

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Target not currently curated in GtoImmuPdb

Target id: 1634

Nomenclature: MMP10

Family: M10: Matrix metallopeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 476 11q22.2 MMP10 matrix metallopeptidase 10
Mouse - 476 9 A1 Mmp10 matrix metallopeptidase 10
Rat - 476 8q11 Mmp10 matrix metallopeptidase 10
Previous and Unofficial Names Click here for help
transin-2 | SL-2 | transformation-associated protein 34A | STMY2 | matrix metallopeptidase 10 (stromelysin 2)
Database Links Click here for help
Specialist databases
MEROPS M10.006 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.24.22

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
CM-352 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 7.8 pIC50 1
pIC50 7.8 (IC50 1.5x10-8 M) [1]

References

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1. Orbe J, Rodríguez JA, Sánchez-Arias JA, Salicio A, Belzunce M, Ugarte A, Chang HC, Rabal O, Oyarzabal J, Páramo JA. (2015) Discovery and safety profiling of a potent preclinical candidate, (4-[4-[[(3R)-3-(hydroxycarbamoyl)-8-azaspiro[4.5]decan-3-yl]sulfonyl]phenoxy]-N-methylbenzamide) (CM-352), for the prevention and treatment of hemorrhage. J Med Chem, 58 (7): 2941-57. [PMID:25686022]

How to cite this page

M10: Matrix metallopeptidase: MMP10. Last modified on 29/08/2017. Accessed on 28/10/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetoimmunopharmacology.org/GRAC/ObjectDisplayForward?objectId=1634.