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GPR152

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Target not currently curated in GtoImmuPdb

Target id: 138

Nomenclature: GPR152

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 470 11q13.2 GPR152 G protein-coupled receptor 152
Mouse 7 511 19 A Gpr152 G protein-coupled receptor 152
Rat 7 394 1q42 Gpr152 G protein-coupled receptor 152
Previous and Unofficial Names Click here for help
PGR1 | PGR5 | G-protein coupled receptor PGR5
Database Links Click here for help
Specialist databases
GPCRdb gp152_human (Hs), gp152_mouse (Mm)
Other databases
Alphafold Q8TDT2 (Hs), Q8BXS7 (Mm)
ChEMBL Target CHEMBL4523900 (Hs)
Ensembl Gene ENSG00000175514 (Hs), ENSMUSG00000044724 (Mm), ENSRNOG00000021912 (Rn)
Entrez Gene 390212 (Hs), 269053 (Mm), 688884 (Rn)
Human Protein Atlas ENSG00000175514 (Hs)
KEGG Gene hsa:390212 (Hs), mmu:269053 (Mm), rno:688884 (Rn)
Pharos Q8TDT2 (Hs)
RefSeq Nucleotide NM_206997 (Hs), NM_206973 (Mm), XM_001068698 (Rn)
RefSeq Protein NP_996880 (Hs), NP_996856 (Mm), XP_001068698 (Rn)
UniProtKB Q8TDT2 (Hs), Q8BXS7 (Mm)
Wikipedia GPR152 (Hs)
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L317V
Global MAF (%):  9
Subpopulation MAF (%):  AFR|AMR: 39|2
Minor allele count:  C=0.093/204
SNP accession:  VAR_059323, rs1638559
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G61R
Global MAF (%):  5
Subpopulation MAF (%):  AMR|ASN: 1|19
Minor allele count:  T=0.054/118
SNP accession:  rs79423227
Validation:  1000 Genomes, Frequency
General Comments
GPR152 is found to be most closely related to the gamma-group of Rhodopsin family [1].

References

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1. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta, 1722 (3): 235-46. [PMID:15777626]

Contributors

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