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GPR151

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Target not currently curated in GtoImmuPdb

Target id: 137

Nomenclature: GPR151

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 419 5q32 GPR151 G protein-coupled receptor 151
Mouse 7 422 18 B3 Gpr151 G protein-coupled receptor 151
Rat 7 421 18p11 Gpr151 G protein-coupled receptor 151
Previous and Unofficial Names Click here for help
GALR4 | G-protein coupled receptor PGR7 | galanin receptor 4
Database Links Click here for help
Specialist databases
GPCRdb gp151_human (Hs), gp151_mouse (Mm), gp151_rat (Rn)
Other databases
Alphafold Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
ChEMBL Target CHEMBL3085617 (Hs)
Ensembl Gene ENSG00000173250 (Hs), ENSMUSG00000042816 (Mm), ENSRNOG00000027103 (Rn)
Entrez Gene 134391 (Hs), 240239 (Mm), 307475 (Rn)
Human Protein Atlas ENSG00000173250 (Hs)
KEGG Gene hsa:134391 (Hs), mmu:240239 (Mm), rno:307475 (Rn)
Pharos Q8TDV0 (Hs)
RefSeq Nucleotide NM_194251 (Hs), NM_181543 (Mm), NM_181633 (Rn)
RefSeq Protein NP_919227 (Hs), NP_853521 (Mm), NP_853664 (Rn)
UniProtKB Q8TDV0 (Hs), Q7TSN6 (Mm), Q7TSN5 (Rn)
Wikipedia GPR151 (Hs)
Agonist Comments
GPR151 responded to galanin with an EC50 value of 2 uM. This suggests that the endogenous ligand shares structural features with galanin [1].
Immuno Process Associations
Immuno Process:  Immune regulation
Tissue Distribution Click here for help
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Human
Technique:  Northern blot
References:  1
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Mouse
Technique:  Northern blot
References:  1
Central nervous system and habenular complex
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Click here for help Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr151tm1Dgen Gpr151tm1Dgen/Gpr151tm1Dgen
involves: 129P2/OlaHsd * C57BL/6		 MGI:2441887  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L261V
Global MAF (%):  36
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 23|22|80|19
Minor allele count:  C=0.363/792
SNP accession:  rs7709485
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  P40L
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR|EUR: 4|7|7
Minor allele count:  A=0.044/97
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs17104742
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A144V
Global MAF (%):  7
Subpopulation MAF (%):  AFR|AMR|ASN: 18|7|6
Minor allele count:  A=0.067/147
SNP accession:  rs7713676
Validation:  1000 Genomes, HapMap, Frequency
General Comments
Both human and mouse GPR151 lack the well-conserved D-R-Y motif downstream of the third transmembrane domain [1].

References

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1. Ignatov A, Hermans-Borgmeyer I, Schaller HC. (2004) Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. Neuropharmacology, 46 (8): 1114-20. [PMID:15111018]

Contributors

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