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Urate anion exchanger 1

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Target not currently curated in GtoImmuPdb

Target id: 1031

Nomenclature: Urate anion exchanger 1

Abbreviated Name: URAT1

Systematic Nomenclature: SLC22A12

Family: Urate transporter

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 12 553 11q13.1 SLC22A12 solute carrier family 22 member 12
Mouse 12 553 19 A Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12
Rat 12 553 1q43 Slc22a12 solute carrier family 22 member 12
Previous and Unofficial Names Click here for help
organic anion transporter 4-like protein | Renal-specific transporter | RST | OAT4L | solute carrier family 22 (organic anion/cation transporter), member 12 | solute carrier family 22 (organic anion/urate transporter), member 12 | solute carrier family 22 (organic anion/cation transporter)
Database Links Click here for help
Specialist databases
Bioparadigms SLC Tables SLC22A12 (Hs)
RESOLUTE SLC22A12 (Hs)
Other databases
Alphafold Q96S37 (Hs), Q8CFZ5 (Mm), Q3ZAV1 (Rn)
ChEMBL Target CHEMBL6120 (Hs), CHEMBL1075239 (Rn)
Ensembl Gene ENSG00000197891 (Hs), ENSMUSG00000061742 (Mm), ENSRNOG00000021108 (Rn)
Entrez Gene 116085 (Hs), 20521 (Mm), 365398 (Rn)
Human Protein Atlas ENSG00000197891 (Hs)
KEGG Gene hsa:116085 (Hs), mmu:20521 (Mm), rno:365398 (Rn)
OMIM 607096 (Hs)
Pharos Q96S37 (Hs)
UniProtKB Q96S37 (Hs), Q8CFZ5 (Mm), Q3ZAV1 (Rn)
Wikipedia SLC22A12 (Hs)
Stoichiometry Click here for help
Unknown

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
dotinurad Small molecule or natural product Approved drug Primary target of this compound Hs Inhibition 6.4 pIC50 3
⤷ pIC50 6.4 (IC50 4x10-7 M) [3]
sufinpyrazone Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 4.0 pIC50 4
⤷ pIC50 4.0 (IC50 1x10-4 M) [4]
lesinurad Small molecule or natural product Approved drug Hs Inhibition - - 1
⤷ [1]
verinurad Small molecule or natural product Hs Inhibition - -
⤷
General Comments
URAT1 as a target for the treatment of hyperuricemia of gout is reviewed in [2].

References

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1. Burns CM, Wortmann RL. (2011) Gout therapeutics: new drugs for an old disease. Lancet, 377 (9760): 165-77. [PMID:20719377]

2. Diaz-Torné C, Perez-Herrero N, Perez-Ruiz F. (2015) New medications in development for the treatment of hyperuricemia of gout. Curr Opin Rheumatol, 27 (2): 164-9. [PMID:25603039]

3. Taniguchi T, Ashizawa N, Matsumoto K, Saito R, Motoki K, Sakai M, Chikamatsu N, Hagihara C, Hashiba M, Iwanaga T. (2019) Pharmacological Evaluation of Dotinurad, a Selective Urate Reabsorption Inhibitor. J Pharmacol Exp Ther, 371 (1): 162-170. [PMID:31371478]

4. Yu Z, Fong WP, Cheng CH. (2007) Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells. Drug Metab Dispos, 35 (6): 981-6. [PMID:17325024]

Contributors

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