The IUPHAR Guide to IMMUNOPHARMACOLOGY ligand list
GtoImmuPdb ligands only: Low molecular weight, non-polymeric compounds produced via either total synthesis or semi-synthetic processes.
| Ligand name | ID | Synonyms | |||||||
| A | Back to top | ||||||||
| 852A |
|
9025 | |||||||
| A286982 |
|
6592 | A 286982, A-286982 | ||||||
| A438079 |
|
4118 | A 438079, A-438079 | ||||||
| AB680 |
|
|
10707 | AB-680 | |||||
| AB928 |
|
11154 | AB-928 | ||||||
| abediterol |
|
9326 | LAS-100977 | ||||||
| abrocitinib |
|
|
9991 | compound 25 [PMID: 29298069], PF-04965842, PF04965842 | |||||
| ABT-737 |
|
|
8320 | ABT 737, ABT737, compound 2 [PMID 17256834] | |||||
| AC430 |
|
9177 | AC-430 | ||||||
| acalabrutinib |
|
|
8912 | ACP-196, Calquence®, Example 6 [US20140155385 A1] | |||||
| ACT-389949 |
|
9511 | |||||||
| acumapimod |
|
9203 | BCT 197, BCT-197, BCT197, compound A [WO2013139809] | ||||||
| adriforant |
|
8985 | PF 3893787, PF-03893787, ZPL-389, ZPL-3893787, ZPL389, ZPL3893787 | ||||||
| ADU-S100 |
|
10192 | dithio-(Rp,Rp)-[cyclic[A(2',5')pA(3',5')p]], MIW815, ML RR-S2 CDA, S100 | ||||||
| agatolimod |
|
9843 | CpG 7909, CpG7909, PF 3512676, PF-3512676, ProMune, VaxImmune | ||||||
| AH10-7 |
|
9899 | |||||||
| AH6809 |
|
1896 | AH 6809, AH-6809 | ||||||
| alcaftadine |
|
|
7587 | Lastacaft®, R-89674 | |||||
| alimemazine |
|
|
7237 | Nedeltran®, trimeprazine | |||||
| 3 alpha-aminocholestane |
|
9564 | 3AC, 3 α-aminocholestane | ||||||
| alvelestat |
|
6476 | AZD 9668, AZD-9668, AZD9668, KB-105160 | ||||||
| AM-461 |
|
10170 | AM461, Compound 1 [WO2011085033] | ||||||
| amcinonide |
|
|
7060 | CL-34699, Cyclocort® | |||||
| amelubant |
|
8463 | BIIL 284, BIIL-284 | ||||||
| AMG319 |
|
|
8917 | AMG 319, AMG-319 | |||||
| aminopyridine 2 |
|
10051 | |||||||
| amiselimod |
|
9319 | Example 1 [US20090137530], MT-1303, MT1303 | ||||||
| amiselimod phosphate |
|
9491 | amiselimod-P, MT-1303-P | ||||||
| amlexanox |
|
|
|
7113 | AA-673, Amlexanox®, Aphthasol®, CHX-3673 | ||||
| ancriviroc |
|
804 | SCH 351125, SCH-351125, SCH-C | ||||||
| andrographolide |
|
9675 | |||||||
| apafant |
|
1860 | WEB 2086 BS, WEB-2086 | ||||||
| apilimod |
|
9859 | LAM-002A (apilimod dimesylate), LAM002A, STA 5326, STA-5326, STA5326 | ||||||
| apratastat |
|
6482 | compound 5h [PMID: 16426848], TMI-05, TMI005 | ||||||
| apremilast |
|
|
7372 | CC-10004, Otezla® | |||||
| arformoterol |
|
|
|
7479 | Brovana®, YM-08316 | ||||
| ARN19702 |
|
|
10120 | ARN-19702, compound 8 [PMID: 27404798] | |||||
| ARN726 |
|
9178 | ARN-726, compound 6 [PMID: 25874594] | ||||||
| (R)-ARN2508 |
|
9000 | compound (-)-10r [PMID: 26774927], example 19 [WO2014023643] | ||||||
| (S)-ARN2508 |
|
|
8999 | compound (+)-10r [PMID: 26774927], example 20 [WO2014023643] | |||||
| arpromidine |
|
1221 | ARP | ||||||
| ARRY-371797 |
|
11095 | ARRY-797, ARRY371797, ARRY797, compound 7 [PMID: 19950901] | ||||||
| ARRY-382 |
|
9108 | ARRY 382, ARRY382 | ||||||
| ARRY-502 |
|
10179 | ARRY502, example 237, enantiomer 1 [WO2009158426A1] | ||||||
| AS101 |
|
437 | ammonium tri-chloro(dioxoethylene-O,O'-)tellurate, AS 101, AS-101 | ||||||
| AS-252424 |
|
10578 | AS252424, compound 26 [PMID: 16789742] | ||||||
| asimadoline |
|
9279 | EMD 61 753, EMD 61753, EMD-61753 | ||||||
| asivatrep |
|
9621 | Example 230 [US7858621], PAC-14028 | ||||||
| ASP4058 |
|
9569 | ASP-4058 | ||||||
| aspirin |
|
|
|
4139 | Acetophen®, acetylsalicylic acid, Aspirin® | ||||
| AT38 |
|
9020 | [3-(aminocarbonyl)furoxan-4-yl]methyl salicylate | ||||||
| atracurium |
|
|
9537 | atracurium besilate, atracurium dibesylate, BW 33A, Tracrium® | |||||
| auranofin |
|
|
6306 | Ridaura®, SK&F-39162, SK-39162 | |||||
| avacopan |
|
|
9450 | CCX-168, CCX168 | |||||
| avadomide |
|
10522 | CC-122, CC122, Compound A [WO2014039960A1] | ||||||
| avapritinib |
|
|
10368 | Ayvakit®, Ayvakyt®, BLU-285, BLU285 | |||||
| AVE 0991 |
|
5579 | AVE-0991, AVE0991 | ||||||
| AX-024 |
|
11253 | AX-24, AX024 | ||||||
| AZ13102909 |
|
9577 | AZ909 | ||||||
| AZ2 |
|
|
10233 | ||||||
| AZ3451 |
|
|
9560 | ||||||
| AZ7188 |
|
9586 | |||||||
| AZ8838 |
|
|
9585 | ||||||
| azacitidine |
|
|
|
6796 | 5-AZAC, 5-azacytidine, ladakamycin, Onureg® (CC-486; oral azacitidine), U-18496, Vidaza® | ||||
| azatadine |
|
|
7119 | Optimine®, SCH-10649 | |||||
| azathioprine |
|
|
7120 | Azasan®, BW-57-322, Imuran® | |||||
| AZD1236 |
|
7844 | AZD 1236, AZD-1236 | ||||||
| AZD1678 |
|
9679 | AZD-1678, compound 49 [PMID: 28947948] | ||||||
| AZD1981 |
|
7680 | AZD 1981, AZD-1981 | ||||||
| AZD2098 |
|
9678 | AZD-2098, compound 47 [PMID: 28947948] | ||||||
| AZD2423 |
|
7825 | AZD 2423, AZD-2423 | ||||||
| AZD3965 |
|
10605 | AZD-3965 | ||||||
| AZD4635 |
|
|
11153 | AZD-4635, imaradenant (proposed INN) | |||||
| AZD5069 |
|
8948 | AZD-5069 | ||||||
| AZD5672 |
|
7686 | AZD 5672, AZD-5672 | ||||||
| AZD5718 |
|
10352 | compound 12 [PMID: 30869888] | ||||||
| AZD6605 |
|
7823 | AZ 11920155, AZ-11920155, AZ11920155, AZD 6605, AZD-6605 | ||||||
| AZD6703 |
|
|
7687 | AZ 12012199, AZ-12012199, AZ12012199, AZD 6703, AZD-6703 | |||||
| AZD8154 |
|
11204 | AZD-8154, Example 1 [WO2018055040A1] | ||||||
| AZD8848 |
|
9256 | DSP-3025 | ||||||
| AZD9056 |
|
7826 | AZD 9056, AZD-9056 | ||||||
| AZD9567 |
|
|
9812 | AZD 9567, AZD-9567, compound 15 [PMID: 29424542], example 1 [WO2016046260A1] | |||||
| AZD9898 |
|
10479 | AZD-9898, example 62 [WO2016177845A1] | ||||||
| azelaic acid |
|
|
|
7484 | Azelex®, Finacea®, ZK-62498 | ||||
| AZ11657312 (salt free) |
|
7722 | |||||||
| B | Back to top | ||||||||
| bafetinib |
|
|
7906 | INNO-406, Lyn-IN-1, NS-187 | |||||
| balamapimod |
|
9925 | MKI-833, MKI833 | ||||||
| bardoxolone |
|
2717 | CDDO, RTA-401 | ||||||
| baricitinib |
|
|
|
7792 | INCB-028050, INCB028050, LY-3009104, LY3009104, Olumiant® | ||||
| BAY 11-7082 |
|
5934 | (E)-3-tosylacrylonitrile, BAY-117082, BAY117082 | ||||||
| BAY-985 |
|
10597 | BAY985, compound 34 [PMID: 31859507] | ||||||
| BAYu9773 |
|
3381 | BAY u9773, BAY-u 9773 | ||||||
| beclometasone |
|
|
7059 | beclomethasone, SCH-18020W | |||||
| beclometasone dipropionate |
|
|
5894 | beclomethasone dipropionate, Beconase®, Qnasl®, Vancenase® | |||||
| belnacasan |
|
9035 | HMR3480, VX-765 | ||||||
| belumosudil |
|
9558 | KD-025, KD025, SLx 2119, SLx2119 | ||||||
| bentamapimod |
|
9926 | AS-602801, AS602801, PGL-5001, PGL5001 | ||||||
| benzodrocortisone |
|
9731 | compound 1 [WO2013071010], hydrocortisone 17-benzoate | ||||||
| 3beta-Hydroxy-20(29)-lupene |
|
9028 | Fagarasterol, Lupeol | ||||||
| BI-1935 |
|
9717 | BI 1935, example 3 [WO2007067836] | ||||||
| BI-1950 |
|
9719 | |||||||
| BI-2545 |
|
|
9791 | BI2545, compound 19 [PMID: 29259743] | |||||
| BI605906 |
|
9357 | 3-Amino-4-(1,1-difluoro- propyl)-6-(4-methanesulfonyl- piperidin-1-yl)-thieno[2,3- b]pyridine-2-carboxylic acid amide, compound 115 [US20070293533] | ||||||
| BI 653048 |
|
9715 | (R)-39, BI 653048 BS H3PO4, BI-653048, BI653048 | ||||||
| BI 665915 |
|
9716 | BI-665915, compound 69 [PMID: 25671290] | ||||||
| BI-6901 |
|
9714 | BI 6901, BI 6901, BI6901, eut-22 | ||||||
| BIIB068 |
|
11178 | BIIB-068, compound 1 [PMID: 32696648] | ||||||
| BIIB091 |
|
11203 | BIIB-091, compound 71 [WO2018191577A1] | ||||||
| bimosiamose |
|
9049 | compound 15e [PMID: 9544210], TBC 1269, TBC-1269, TBC1269 | ||||||
| bindarit |
|
11124 | AF-2838, AF2838 | ||||||
| BIRT 377 |
|
9720 | BIRT-377 | ||||||
| BLZ945 |
|
8250 | BLZ 945, BLZ-945 | ||||||
| BML-281 |
|
9664 | compound 3 [PMID: 18642892] | ||||||
| BMS-1001 |
|
10191 | BMS1001, Example 1001 [WO2015160641A2] | ||||||
| BMS-1166 |
|
9608 | compound 2c [PMID: 28613862], Example 1166 [WO2015160641A2] | ||||||
| BMS-202 |
|
|
9607 | compound 1c [PMID: 28613862], PD1-PDL1 inhibitor 2 | |||||
| BMS-345541 |
|
5669 | BMS 345541, BMS345541 | ||||||
| BMS-509744 |
|
9994 | BMS 509744, BMS509744, compound 3 [PMID:16682193] | ||||||
| BMS-561392 |
|
6509 | BMS 561392, BMS561392, DPC-333 | ||||||
| BMS-582949 |
|
|
7838 | BMS 582949, BMS582949, PS 540446, PS-540446, PS540446 | |||||
| BMS-681 |
|
|
9430 | compound 13d [PMID: 25893046] | |||||
| BMS-817399 |
|
|
9497 | compound 29 [PMID: 25101488] | |||||
| BMS-986142 |
|
|
9857 | BMS986142, compound 14f [PMID: 27583770] | |||||
| BMS-986166 |
|
11493 | BMS986166, compound 14a [PMID: 30785748] | ||||||
| BMS-986235 |
|
11024 | BMS986235, compound 13c [PMID: 32407089], LAR-1219, LAR1219 | ||||||
| BMS-986260 |
|
|
10662 | BMS986260, compound 10 [Velaparthi et al., 2020], Example 32' [WO2016140884A1] | |||||
| BMS-986104 derivative 12 |
|
11494 | compound 12 [PMID: 33492963] | ||||||
| BMS-986104 derivative 24 |
|
11495 | compound 24 [PMID: 33492963] | ||||||
| bortezomib |
|
|
|
|
6391 | peptide boronate, PS-341, Velcade® | |||
| bosutinib |
|
|
|
5710 | Bosulif®, SK 606, SK-606, SKI 606 | ||||
| branebrutinib |
|
9869 | BMS-986195, BMS986195, Example 223 [US20160115126A1] | ||||||
| brensocatib |
|
9412 | AZD7986, compound 30, INS 1007, INS1007 | ||||||
| brepocitinib |
|
|
10459 | compound 23 [PMID: 30113844], PF-06700841, PF06700841 | |||||
| brimonidine |
|
|
520 | Alphagan®, Lumify®, Mirvaso®, UK14,304, UK14304 | |||||
| BRL-15572 |
|
10 | BRL 15572, BRL-15,572, BRL15572 | ||||||
| bromfenac |
|
|
|
7131 | AHR-10282B, Bromday®, Prolensa®, Xibrom® | ||||
| BT-11 |
|
10363 | analogue 7 [PMID: 27933891], BT11, Example 1 [US9556146B2] | ||||||
| BTK inhibitor 4b |
|
10094 | compound 4b [PMID: 30216722] | ||||||
| BTP2 |
|
2438 | YM-58483 | ||||||
| BX 471 |
|
767 | BX-471, BX-741 | ||||||
| BX-795 |
|
|
8006 | BX 795, BX795 | |||||
| C | Back to top | ||||||||
| C108297 |
|
9180 | Compound 52 [PMID:18226897] | ||||||
| C1-27 |
|
|
10719 | GSTO1-IN-1 | |||||
| C391 |
|
9570 | compound 5 [PMID: 27994760] | ||||||
| C646 |
|
7004 | |||||||
| canertinib |
|
5675 | CI 1033, CI-1033, PD 183805 dihydrochloride | ||||||
| carotegrast |
|
10511 | HCA2969 | ||||||
| carotegrast methyl |
|
10510 | AJM-300, AJM300 | ||||||
| carprofen |
|
|
7141 | Ro-205720000 | |||||
| CBS-3595 |
|
9610 | |||||||
| CC-885 |
|
9224 | |||||||
| CCR2-RA-[R] |
|
|
9431 | analog 49 (Dasse et al., 2007) | |||||
| CCX354 |
|
10164 | CCX 354, CCX-354, CCX-354-C | ||||||
| CDP840 |
|
9330 | CDP 840, CDP-840 | ||||||
| celecoxib |
|
|
|
2892 | Celecox®, Elyxyb® (DFN-15; oral solution), Onsenal®, SC-58635, SC58635 | ||||
| cenerimod |
|
9824 | ACT-334441 | ||||||
| cenicriviroc |
|
801 | TAK 652, TAK-652, TAK652, TBR-652 | ||||||
| cerdulatinib |
|
8957 | PRT 062070, PRT-062070, PRT-2070, PRT062070 | ||||||
| cetirizine |
|
|
1222 | Reactine®, Zyrtec® | |||||
| CG200745 |
|
10055 | CG-2, CG-200745, HDCG-0745 | ||||||
| 2'3'-cGAMP |
|
|
9207 | cyclic [G(2',5')pA(3',5')p], cyclic GMP-AMP, Cyclic guanosine monophosphate-adenosine monophosphate | |||||
| CGI1746 |
|
|
8066 | CGI 1746, CGI-1746 | |||||
| CGI560 |
|
9264 | CGI-560 | ||||||
| CH-4051 |
|
9844 | Formula (10) [WO2012078708A1] | ||||||
| chloroquine |
|
|
|
|
5535 | Aralen®, chloraquine, Malaquin® | |||
| CHMFL-BTK-11 |
|
9516 | |||||||
| cicaprost |
|
1917 | ZK 96480, ZK-96480 | ||||||
| ciclesonide |
|
|
7469 | Alvesco®, Omnaris®, RPR-251526 | |||||
| ciforadenant |
|
10190 | CPI-444, CPI444, V-81444, V81444 | ||||||
| cilomilast |
|
|
7407 | SB-207499 | |||||
| cintirorgon |
|
10045 | compound 32J [WO2016201225A1], LYC-55716, LYC55716 | ||||||
| cipemastat |
|
6466 | Ro 28-2653 | ||||||
| clemastine |
|
|
6063 | HS-592, meclastin, Tavegil®, Tavist® | |||||
| clemizole |
|
10285 | |||||||
| clobenpropit |
|
1223 | VUF 9153, VUF-9153 | ||||||
| clobetasol propionate |
|
|
7062 | CCI-4725, Clobex®, Dermovate®, GR 2/925, Temovate® | |||||
| clobetasone |
|
|
9088 | Eumovate® | |||||
| clodronic acid |
|
|
9605 | Bonefos®, Clasteon ®, clodronate, Loron® | |||||
| clofazimine |
|
|
9184 | Lamprene® | |||||
| clopidogrel (active metabolite) |
|
1772 | |||||||
| CM4620 |
|
10087 | CM-4620, compound I [WO2016138472A1] | ||||||
| CNX-774 |
|
9266 | |||||||
| colchicine |
|
|
|
2367 | Colcrys®, methoxylated analogue of XD1, XD25 | ||||
| compound 48/80 |
|
5531 | |||||||
| compound 3a [Pipionne et al, 2018] |
|
9965 | |||||||
| compound 10a [PMID: 31283223] |
|
10435 | |||||||
| compound 12a [PMID: 29031075] |
|
9684 | |||||||
| compound 19a [PMID: 26506089] |
|
9842 | |||||||
| compound 8a [PMID: 23713581] |
|
8856 | |||||||
| compound 21b [PMID: 31136173] |
|
10403 | |||||||
| compound 5b [PMID: 29457898] |
|
9835 | |||||||
| compound 5b [PMID: 31287314] |
|
10434 | |||||||
| compound 18c [PMID: 25901531] |
|
9227 | |||||||
| compound 7c [PMID: 22041175] |
|
9931 | |||||||
| compound 8c [PMID: 28760529] |
|
9671 | |||||||
| Compound 9 [doi:10.26434/chemrxiv.7072592.v1] |
|
10083 | |||||||
| compound 17d [PMID: 23099093] |
|
8196 | |||||||
| compound 5d [PMID: 31335136] |
|
10441 | Example 59 [WO2018121550] | ||||||
| compound 7d [PMID: 29672049] |
|
9937 | |||||||
| compound 18e [PMID: 31670517] |
|
10549 | |||||||
| compound 5e [PMID: 28580438] |
|
9712 | |||||||
| compound 20f [PMID: 28520415] |
|
9961 | |||||||
| compound 7f [PMID: 29191554] |
|
|
9794 | example 32 [WO2011078413] | |||||
| compound 7f [PMID: 29283260] |
|
9780 | |||||||
| compound 2g [PMID: 27390066] |
|
9682 | |||||||
| compound 4g [PMID: 2680437] |
|
9198 | |||||||
| compound 8ic [PMID: 19081254] |
|
9478 | CCR4 Antagonist | ||||||
| compound III [PMID: 24045148] |
|
9709 | |||||||
| compound II [PMID: 21329883] |
|
9579 | |||||||
| compound 16i [PMID: 31525963] |
|
10502 | |||||||
| compound 9 [Kumar et al., 2019] |
|
10448 | |||||||
| compound 17l [PMID: 26288691] |
|
10035 | |||||||
| compound 29 [Moslin et al., 2017] |
|
9992 | |||||||
| compound 12p [Larson et al., 2017] |
|
9690 | |||||||
| compound 10 [PMID: 31411465] |
|
10488 | example 8 (cis racemate) [WO2017060855A1] | ||||||
| compound 11 [PMID: 29442501] |
|
9819 | |||||||
| compound 12 [PMID: 27448772] |
|
|
9453 | ||||||
| compound 15 [PMID: 25411721] |
|
9078 | example 252 [WO2007110237] | ||||||
| compound 15 [PMID: 29852070] |
|
9997 | |||||||
| compound 15 [PMID: 32045236] |
|
10706 | |||||||
| compound 16 [PMID: 26794040] |
|
9223 | |||||||
| compound 16 [PMID: 31525966] |
|
10501 | |||||||
| compound 17 [PMID: 29741897] |
|
10005 | |||||||
| compound 1 [PMID: 24930776] |
|
9092 | DB36 | ||||||
| compound 1 [PMID: 28611375] |
|
9673 | |||||||
| compound 1 [PMID: 31477924] |
|
10481 | |||||||
| compound 21 [PMID: 22802221] |
|
6918 | C21 | ||||||
| compound 21 [PMID: 24900635] |
|
8187 | |||||||
| compound 24 [PMID: 26987013 ] |
|
9252 | |||||||
| compound 25 [PMID: 28038940] |
|
9700 | |||||||
| compound 25 [PMID: 31260299] |
|
10428 | |||||||
| compound 25 [PMID: 32105470] |
|
10718 | |||||||
| compound 25 [PMID: 32687365] |
|
11130 | |||||||
| compound 26 [PMID: 31710475] |
|
10602 | |||||||
| compound 27 [PMID: 24900635] |
|
10133 | |||||||
| compound 28 [PMID: 28671460] |
|
9670 | |||||||
| compound 29 [PMID: 31934767] |
|
10596 | |||||||
| compound 2 [PMID: 28621538] |
|
|
11282 | example 727 [WO2012093101A1] | |||||
| compound 31 [PMID: 31259550] |
|
10417 | |||||||
| compound 32 [PMID: 31638797] |
|
10528 | example 69 [WO2016179460A1] | ||||||
| compound 36 [PMID: 21958547] |
|
9391 | |||||||
| compound 37 [PMID: 29193967] |
|
9797 | |||||||
| compound 39 [PMID: 31742400] |
|
10585 | |||||||
| compound 3 [PMID: 28603634] |
|
9628 | |||||||
| compound 3 [PMID: 29633584] |
|
9960 | |||||||
| compound 41 [PMID: 25000588] |
|
9349 | |||||||
| compound 41 [PMID: 31855425] |
|
|
10598 | ||||||
| compound 43 [PMID: 26751273] |
|
9492 | |||||||
| compound 47 [PMID: 28737909] |
|
9646 | |||||||
| compound 52 [PMID: 28541707] |
|
10001 | |||||||
| compound 76 [PMID: 28657314] |
|
9609 | |||||||
| compound 7 [PMID: 31381331] |
|
10450 | |||||||
| compound 8 [PMID: 25898023] |
|
10498 | |||||||
| compound 9 [PMID: 26006010] |
|
9761 | |||||||
| compound 2q [PMID: 30986068] |
|
||||||||