gefapixant   Click here for help

GtoPdb Ligand ID: 9540

Synonyms: AF-219 | AF219 | Lyfnua® | MK7264 | MK‐7264
Approved drug PDB Ligand Immunopharmacology Ligand
gefapixant is an approved drug (Japan (2022), EMA (2023))
Compound class: Synthetic organic
Comment: Gefapixant (MK‐7264, and formerly AF-219) is a P2X3 and P2X2/3 receptor antagonist. Experimental results have shown that gefapixant acts as a reversible allosteric antagonist, that exhibits preferential activity at closed channels.
Studies in rodent models have provided evidence that supports investigation of gefapixant as a novel treatment for chronic sensitisation conditions [7].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 164.82
Molecular weight 353.12
XLogP 0.6
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES COc1cc(C(C)C)c(cc1S(=O)(=O)N)Oc1cnc(nc1N)N
Isomeric SMILES COc1cc(C(C)C)c(cc1S(=O)(=O)N)Oc1cnc(nc1N)N
InChI InChI=1S/C14H19N5O4S/c1-7(2)8-4-10(22-3)12(24(17,20)21)5-9(8)23-11-6-18-14(16)19-13(11)15/h4-7H,1-3H3,(H2,17,20,21)(H4,15,16,18,19)
InChI Key HLWURFKMDLAKOD-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan (2022), EMA (2023))
IUPAC Name Click here for help
5-(2,4-diaminopyrimidin-5-yl)oxy-2-methoxy-4-propan-2-ylbenzenesulfonamide
International Nonproprietary Names Click here for help
INN number INN
10642 gefapixant
Synonyms Click here for help
AF-219 | AF219 | Lyfnua® | MK7264 | MK‐7264
Database Links Click here for help
GtoPdb PubChem SID 336446926
PubChem CID 24764487
RCSB PDB Ligand AF9, AF9
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UniChem Compound Search for chemical match using the InChIKey HLWURFKMDLAKOD-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey HLWURFKMDLAKOD-UHFFFAOYSA-N