romiplostim   Click here for help

GtoPdb Ligand ID: 6974

Synonyms: MG531 | Nplate®
Approved drug Immunopharmacology Ligand
romiplostim is an approved drug (FDA (2008), EMA (2009))
Compound class: Peptide or derivative
Comment: This drug is a thrombopoietin receptor agonist, although its peptide sequence does not resemble that of the endogenous peptide thrombopoietin. Romiplostim is known as a peptibody, a fusion between the Fc portion of immunoglobulin and a therapeutic peptide. In this case the drug exists as a heterodimer. The carboxy terminal 14 amino acid residues of this peptibody constitute the thrombopoietin receptor binding domain (single letter amino acid code: IEGPTLRQWLAARA).
Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (FDA (2008), EMA (2009))
International Nonproprietary Names Click here for help
INN number INN
8587 romiplostim
Synonyms Click here for help
MG531 | Nplate®
Database Links Click here for help
CAS Registry No. 267639-76-9 (source: Scifinder)
ChEMBL Ligand CHEMBL1201832
DrugBank Ligand DB05332
GtoPdb PubChem SID 178103553
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