cyclic AMP   Click here for help

GtoPdb Ligand ID: 2352

Abbreviated name: cAMP
Synonyms: 3' 5'-adenosine monophosphate | 3',5'-cyclic AMP | cyclic adenosine monophosphate
PDB Ligand
Compound class: Metabolite or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 164.65
Molecular weight 329.05
XLogP -2.49
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC1C2OP(=O)(O)OCC2OC1n1cnc2c1ncnc2N
Isomeric SMILES O[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]2O[C@H]1n1cnc2c1ncnc2N
InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChI Key IVOMOUWHDPKRLL-KQYNXXCUSA-N
Classification Click here for help
Compound class Metabolite or derivative
IUPAC Name Click here for help
(1S,6R,8R,9R)-8-(6-aminopurin-9-yl)-3-hydroxy-3-oxo-2,4,7-trioxa-3$l^{5}-phosphabicyclo[4.3.0]nonan-9-ol
Synonyms Click here for help
3' 5'-adenosine monophosphate | 3',5'-cyclic AMP | cyclic adenosine monophosphate
Database Links Click here for help
CAS Registry No. 60-92-4
ChEBI CHEBI:17489
ChEMBL Ligand CHEMBL316966
DrugBank Ligand DB02527
GtoPdb PubChem SID 135651452
PubChem CID 6076
RCSB PDB Ligand CMP
Search Google for chemical match using the InChIKey IVOMOUWHDPKRLL-KQYNXXCUSA-N
Search Google for chemicals with the same backbone IVOMOUWHDPKRLL
SynPHARM 5496 (in complex with HCN1)
5504 (in complex with HCN2)
UniChem Compound Search for chemical match using the InChIKey IVOMOUWHDPKRLL-KQYNXXCUSA-N
UniChem Connectivity Search for chemical match using the InChIKey IVOMOUWHDPKRLL-KQYNXXCUSA-N
Wikipedia Cyclic_adenosine_monophosphate