Subunits

vitronectin V65 subunit

vitronectin V10 subunit

Peptide Sequence

DQESCKGRCTEGFNVDKKCQCDELCSYYQSCCTDYTAECKPQVTRGDVFTMPEDEYTVYDDGEEKNNATVHEQVGGPSLT SDLQAQSKGNPEQTPVLKPEEEAPAPEVGASKPEGIDSRPETLHPGRPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQY CYELDEKAVRPGYPKLIRDVWGIEGPIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALA LPAHSYSGRERVYFFKGKQYWEYQFQHQPSQEECEGSSLSAVFEHFAMMQRDSWEDIFELLFWGRTSAGTRQPQFISRDW HGVPGQVDAAMAGRIYISGMAPRPSLAKKQRFRHRNRKGYRSQRGHSRGRNQNSRRPSRATWLSLFSSEESNLGANNYDD YRMDWLVPATCEPIQSVFFF

Asp-Gln-Glu-Ser-Cys-Lys-Gly-Arg-Cys-Thr-Glu-Gly-Phe-Asn-Val-Asp-Lys-Lys-Cys-Gln-Cys-Asp-Glu-Leu-Cys-Ser-Tyr-Tyr-Gln-Ser-Cys-Cys-Thr-Asp-Tyr-Thr-Ala-Glu-Cys-Lys-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-Glu-Asp-Glu-Tyr-Thr-Val-Tyr-Asp-Asp-Gly-Glu-Glu-Lys-Asn-Asn-Ala-Thr-Val-His-Glu-Gln-Val-Gly-Gly-Pro-Ser-Leu-Thr-Ser-Asp-Leu-Gln-Ala-Gln-Ser-Lys-Gly-Asn-Pro-Glu-Gln-Thr-Pro-Val-Leu-Lys-Pro-Glu-Glu-Glu-Ala-Pro-Ala-Pro-Glu-Val-Gly-Ala-Ser-Lys-Pro-Glu-Gly-Ile-Asp-Ser-Arg-Pro-Glu-Thr-Leu-His-Pro-Gly-Arg-Pro-Gln-Pro-Pro-Ala-Glu-Glu-Glu-Leu-Cys-Ser-Gly-Lys-Pro-Phe-Asp-Ala-Phe-Thr-Asp-Leu-Lys-Asn-Gly-Ser-Leu-Phe-Ala-Phe-Arg-Gly-Gln-Tyr-Cys-Tyr-Glu-Leu-Asp-Glu-Lys-Ala-Val-Arg-Pro-Gly-Tyr-Pro-Lys-Leu-Ile-Arg-Asp-Val-Trp-Gly-Ile-Glu-Gly-Pro-Ile-Asp-Ala-Ala-Phe-Thr-Arg-Ile-Asn-Cys-Gln-Gly-Lys-Thr-Tyr-Leu-Phe-Lys-Gly-Ser-Gln-Tyr-Trp-Arg-Phe-Glu-Asp-Gly-Val-Leu-Asp-Pro-Asp-Tyr-Pro-Arg-Asn-Ile-Ser-Asp-Gly-Phe-Asp-Gly-Ile-Pro-Asp-Asn-Val-Asp-Ala-Ala-Leu-Ala-Leu-Pro-Ala-His-Ser-Tyr-Ser-Gly-Arg-Glu-Arg-Val-Tyr-Phe-Phe-Lys-Gly-Lys-Gln-Tyr-Trp-Glu-Tyr-Gln-Phe-Gln-His-Gln-Pro-Ser-Gln-Glu-Glu-Cys-Glu-Gly-Ser-Ser-Leu-Ser-Ala-Val-Phe-Glu-His-Phe-Ala-Met-Met-Gln-Arg-Asp-Ser-Trp-Glu-Asp-Ile-Phe-Glu-Leu-Leu-Phe-Trp-Gly-Arg-Thr-Ser-Ala-Gly-Thr-Arg-Gln-Pro-Gln-Phe-Ile-Ser-Arg-Asp-Trp-His-Gly-Val-Pro-Gly-Gln-Val-Asp-Ala-Ala-Met-Ala-Gly-Arg-Ile-Tyr-Ile-Ser-Gly-Met-Ala-Pro-Arg-Pro-Ser-Leu-Ala-Lys-Lys-Gln-Arg-Phe-Arg-His-Arg-Asn-Arg-Lys-Gly-Tyr-Arg-Ser-Gln-Arg-Gly-His-Ser-Arg-Gly-Arg-Asn-Gln-Asn-Ser-Arg-Arg-Pro-Ser-Arg-Ala-Thr-Trp-Leu-Ser-Leu-Phe-Ser-Ser-Glu-Glu-Ser-Asn-Leu-Gly-Ala-Asn-Asn-Tyr-Asp-Asp-Tyr-Arg-Met-Asp-Trp-Leu-Val-Pro-Ala-Thr-Cys-Glu-Pro-Ile-Gln-Ser-Val-Phe-Phe-Phe

Post-translational Modification

The vitronectin precursor protein can be cleaved into three subunits: vitronectin V65 subunit, vitronectin V10 subunit and somatomedin-B. Vitronectin can exist in two forms, one being a single chain uncleaved form (V75), and the other a cleaved form composed of the V65 and V10 subunits which are held together by a disulfide bond.