[125I]DTyr-Gly-[(Nle28,31)CCK-26-33   Click here for help

GtoPdb Ligand ID: 6666

 Ligand is labelled  Ligand is radioactive
Compound class: Peptide or derivative
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Peptide Sequence Click here for help
YGDYXGWXDF
Tyr-Gly-Asp-Tys-Nle-Gly-Trp-Nle-Asp-Phe
Chemical Modification
The native sequence of CCK 26-33 is Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-Asp. C terminal tyrosine at position 1 is the D isomer, Tyr4 is sulphated (OSO3H shown as Tys), and the N terminal is amidated. Both methionines are replaced with norleucine (Nle). Iodinated on the tyrosine at position 1.