fenclonine   Click here for help

GtoPdb Ligand ID: 5240

Synonyms: 4-chlorophenylalanine | p-Chlorophenylalanine | para-chlorophenylalanine | PCPA
Compound class: Synthetic organic
Comment: A synthetic amino acid which covalently binds to tryptophan hydroxylase to cause depletion of serotonin in the brain [1].

fenclonine is commercially available from our sponsors

2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 63.32
Molecular weight 199.04
XLogP -0.76
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES NC(C(=O)O)Cc1ccc(cc1)Cl
Isomeric SMILES NC(C(=O)O)Cc1ccc(cc1)Cl
InChI InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI Key NIGWMJHCCYYCSF-UHFFFAOYSA-N

For advanced searching click here to open chemical structure editor

Similar Ligands Click here for help
L-phenylalanine
Click here for ligand page
Targets
GPR139; ATB0,+; B0AT1; B0AT2; B0AT3; CaS receptor; L-Phenylalanine hydroxylase ; L-type amino acid transporter 3; L-type amino acid transporter 4; Monocarboxylate transporter 10; sodium-coupled neutral amino acid transporter 2; sodium-coupled neutral amino acid transporter 4
L-tyrosine
Click here for ligand page
Targets
L-Tyrosine hydroxylase ; Monocarboxylate transporter 10; sodium-coupled neutral amino acid transporter 1
α-methylphenylalanine
Click here for ligand page
Targets
L-Phenylalanine hydroxylase
methyltyrosine
Click here for ligand page
Targets
L-Tyrosine hydroxylase
D-phenylalanine
Click here for ligand page
Targets
HCA3 receptor
alpha-methyltyrosine
Click here for ligand page
Targets
L-Tyrosine hydroxylase