anatumomab mafenatox   Click here for help

GtoPdb Ligand ID: 9947

Synonyms: 5T4FabV13SEAD227A | ABR 214936 | ABR-214936 | ABR214936 | pMB125 | PNU 214936 | PNU-214936 | PNU214936 | TTS-CD2
Immunopharmacology Ligand
Compound class: Antibody
Comment: Anatumomab mafenatox (ABR-214936) is a fusion protein containing an engineered 5T4 Fab moiety fused via the C terminus of the heavy chain to a mutated form of the Staphylococcal enterotoxin A (SEA) superantigen [1]. SEA is secreted by the pathogen and it stimulates a massive MHC class II-T cell receptor-mediated polyclonal T cell activation, which results in the release of large amounts of cytotoxic and proinflammatory cytokines. Anatumomab mafenatox targets the destructive power of SEA to 5T4-expressing tumour cells. The Asp227Ala mutation is the SEA moiety is designed to reduce MHC class II binding affinity so as to reduce killing of MHC class II positive cells.
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1. Forsberg G, Ohlsson L, Brodin T, Björk P, Lando PA, Shaw D, Stern PL, Dohlsten M. (2001)
Therapy of human non-small-cell lung carcinoma using antibody targeting of a modified superantigen.
Br J Cancer, 85 (1): 129-36. [PMID:11437414]
2. Shaw DM, Connolly NB, Patel PM, Kilany S, Hedlund G, Nordle O, Forsberg G, Zweit J, Stern PL, Hawkins RE. (2007)
A phase II study of a 5T4 oncofoetal antigen tumour-targeted superantigen (ABR-214936) therapy in patients with advanced renal cell carcinoma.
Br J Cancer, 96 (4): 567-74. [PMID:17285137]