bococizumab   Click here for help

GtoPdb Ligand ID: 7730

Synonyms: PF-04950615 | RN-316 | RN316
Compound class: Antibody
Comment: Bococizumab is an experimental monoclonal antibody directed against PCSK9 [1]. Anti-PCSK9 antibodies are under intense clinical lead scrutiny, as the successors to statins for the treatment of hyperlipidemia and associated atherosclerotic cardiovascular disease. Peptide sequences for this antibody are available from its IMGT link. Based on sequence alignment bococizumab relates to antibody clone L1L3 in patent US8080243, with SEQ IDs 53 and 54 matching the sequences in the INN record for bococizumab.
Click here for help
1. Liang H et al
Isolated antibody which specifically binds to PCSK9.
Patent number: US8080243. Assignee: Rinat Neuroscience Corp., Pfizer Inc.. Priority date: 12/09/2008. Publication date: 20/12/2011.