CCL8   Click here for help

GtoPdb Ligand ID: 772

Synonyms: monocyte chemotactic protein-2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: CCL8 (also known as MCP-2) is a CC family chemokine.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Blaszczyk J, Coillie EV, Proost P, Damme JV, Opdenakker G, Bujacz GD, Wang JM, Ji X. (2000)
Complete crystal structure of monocyte chemotactic protein-2, a CC chemokine that interacts with multiple receptors.
Biochemistry, 39 (46): 14075-81. [PMID:11087354]
2. Lüttichau HR, Clark-Lewis I, Jensen PØ, Moser C, Gerstoft J, Schwartz TW. (2003)
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6.
J Biol Chem, 278 (13): 10928-33. [PMID:12554737]
3. Proost P, Struyf S, Couvreur M, Lenaerts JP, Conings R, Menten P, Verhaert P, Wuyts A, Van Damme J. (1998)
Posttranslational modifications affect the activity of the human monocyte chemotactic proteins MCP-1 and MCP-2: identification of MCP-2(6-76) as a natural chemokine inhibitor.
J Immunol, 160 (8): 4034-41. [PMID:9558113]
4. Ruffing N, Sullivan N, Sharmeen L, Sodroski J, Wu L. (1998)
CCR5 has an expanded ligand-binding repertoire and is the primary receptor used by MCP-2 on activated T cells.
Cell Immunol, 189 (2): 160-8. [PMID:9790730]