alfuzosin   Click here for help

GtoPdb Ligand ID: 7109

Synonyms: SL-77499-10 | SL-7749910 | Uroxatral®
Approved drug
alfuzosin is an approved drug (FDA (2003))
Compound class: Synthetic organic
Comment: Alfuzosin is an α1-adrenergic receptor antagonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 116.05
Molecular weight 389.21
XLogP 3.04
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C
Isomeric SMILES COc1cc2nc([nH]c(=N)c2cc1OC)N(CCCN=C(C1CCCO1)O)C
InChI InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
1. Hieble JP. (2000)
Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics.
Pharm Acta Helv, 74 (2-3): 163-71. [PMID:10812954]
2. Hieble JP, Bondinell WE, Ruffolo Jr RR. (1995)
Alpha- and beta-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification.
J Med Chem, 38 (18): 3415-44. [PMID:7658428]