adrenomedullin   Click here for help

GtoPdb Ligand ID: 697

Abbreviated name: AM
Compound class: Endogenous peptide in human, mouse or rat
Species: Rat
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Aldecoa A, Gujer R, Fischer JA, Born W. (2000)
Mammalian calcitonin receptor-like receptor/receptor activity modifying protein complexes define calcitonin gene-related peptide and adrenomedullin receptors in Drosophila Schneider 2 cells.
FEBS Lett, 471 (2-3): 156-60. [PMID:10767413]
2. Bühlmann N, Leuthäuser K, Muff R, Fischer JA, Born W. (1999)
A receptor activity modifying protein (RAMP)2-dependent adrenomedullin receptor is a calcitonin gene-related peptide receptor when coexpressed with human RAMP1.
Endocrinology, 140 (6): 2883-90. [PMID:10342881]
3. Husmann K, Born W, Fischer JA, Muff R. (2003)
Three receptor-activity-modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cells.
Biochem Pharmacol, 66 (11): 2107-15. [PMID:14609735]
4. Husmann K, Sexton PM, Fischer JA, Born W. (2000)
Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function.
Mol Cell Endocrinol, 162 (1-2): 35-43. [PMID:10854696]
5. Kapas S, Catt KJ, Clark AJ. (1995)
Cloning and expression of cDNA encoding a rat adrenomedullin receptor.
J Biol Chem, 270 (43): 25344-7. [PMID:7592696]
6. Kapas S, Clark AJ. (1995)
Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor.
Biochem Biophys Res Commun, 217 (3): 832-8. [PMID:8554605]
7. Oliver KR, Kane SA, Salvatore CA, Mallee JJ, Kinsey AM, Koblan KS, Keyvan-Fouladi N, Heavens RP, Wainwright A, Jacobson M et al.. (2001)
Cloning, characterization and central nervous system distribution of receptor activity modifying proteins in the rat.
Eur J Neurosci, 14 (4): 618-28. [PMID:11556887]