rilonacept

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Ligands
rilonacept

GtoPdb Ligand ID: 6790

Synonyms: Arcalyst® | IL-1 Trap | interleukin-1 Trap

rilonacept is an approved drug (FDA (2008), EMA (2009))

Comment: Rilonacept is a fusion protein consisting of the binding domains of the IL-1 receptor (IL-1R) and the IL-1 receptor accessory protein (IL-1RAcP) linked to the Fc portion of human IgG1.

Summary
Biological activity
Clinical data
References
Structure
Similar ligands
Immunopharmacology

References
1. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N et al.. (2008) Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum, 58 (8): 2443-52. [PMID:18668535]
2. McDermott MF. (2009) Rilonacept in the treatment of chronic inflammatory disorders. Drugs Today, 45 (6): 423-30. [PMID:19649332]

References

1. Hoffman HM, Throne ML, Amar NJ, Sebai M, Kivitz AJ, Kavanaugh A, Weinstein SP, Belomestnov P, Yancopoulos GD, Stahl N et al.. (2008)
Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Arthritis Rheum, 58 (8): 2443-52. [PMID:18668535]

2. McDermott MF. (2009)
Rilonacept in the treatment of chronic inflammatory disorders.
Drugs Today, 45 (6): 423-30. [PMID:19649332]