IL-37   Click here for help

GtoPdb Ligand ID: 6149

Synonyms: IL-1ζ | IL-23 | interleukin-1ζ | interleukin-1-related protein (IL1RP) | interleukin-23
Immunopharmacology Ligand
Comment: IL-37 is an anti-inflammatory cytokine of the innate immune system.
Species: Human
1. Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Mantovani A, Dagna L, Joosten LA, Dinarello CA. (2016)
Treating experimental arthritis with the innate immune inhibitor interleukin-37 reduces joint and systemic inflammation.
Rheumatology (Oxford), 55 (12): 2220-2229. [PMID:27567100]
2. Nold MF, Nold-Petry CA, Zepp JA, Palmer BE, Bufler P, Dinarello CA. (2010)
IL-37 is a fundamental inhibitor of innate immunity.
Nat Immunol, 11 (11): 1014-22. [PMID:20935647]
3. Nold-Petry CA, Lo CY, Rudloff I, Elgass KD, Li S, Gantier MP, Lotz-Havla AS, Gersting SW, Cho SX, Lao JC et al.. (2015)
IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction.
Nat Immunol, 16 (4): 354-65. [PMID:25729923]