OX-40 ligand

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Ligands
OX-40 ligand (Human)

GtoPdb Ligand ID: 5076

Synonyms: glycoprotein Gp34 | TXGP-1

Compound class: Endogenous peptide in human, mouse or rat

Comment: OX40L (CD252) is the ligand for tumor necrosis factor receptor superfamily, member 4 (TNFRSF4, a.k.a. OX40 or CD134). OX40 is a secondary co-stimulatory immune checkpoint molecule expressed on activated T cells (requiring CD28 co-stimulatory signal), and OX40L is expressed on activated dendritic cells. The OX40/OX40L pair is involved in late T-cell costimulatory signaling and both are transiently expressed following antigen recognition, and blocking OX40/OX40L is reported to prevent the development of disease in in vivo autoimmune and inflammatory disease models [4]. The OX40/OX40L pathway is being investigated for the development of novel anti-inflammatory therapeutics and anti-cancer drugs.
An antibody binding mouse OX40L

Species: Human

References
1. Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A et al.. (2016) OX40L blockade protects against inflammation-driven fibrosis. Proc Natl Acad Sci USA, 113 (27): E3901-10. [PMID:27298374]
2. Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC et al.. (2014) OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis. Proc Natl Acad Sci USA, 111 (6): 2289-94. [PMID:24469824]
3. Komura K, Yoshizaki A, Kodera M, Iwata Y, Ogawa F, Shimizu K, Wayaku T, Yukami T, Murata M, Hasegawa M et al.. (2008) Increased serum soluble OX40 in patients with systemic sclerosis. J Rheumatol, 35 (12): 2359-62. [PMID:18843780]
4. Webb GJ, Hirschfield GM, Lane PJ. (2016) OX40, OX40L and Autoimmunity: a Comprehensive Review. Clin Rev Allergy Immunol, 50 (3): 312-32. [PMID:26215166]

References

1. Elhai M, Avouac J, Hoffmann-Vold AM, Ruzehaji N, Amiar O, Ruiz B, Brahiti H, Ponsoye M, Fréchet M, Burgevin A et al.. (2016)
OX40L blockade protects against inflammation-driven fibrosis.
Proc Natl Acad Sci USA, 113 (27): E3901-10. [PMID:27298374]

2. Gwyer Findlay E, Danks L, Madden J, Cavanagh MM, McNamee K, McCann F, Snelgrove RJ, Shaw S, Feldmann M, Taylor PC et al.. (2014)
OX40L blockade is therapeutic in arthritis, despite promoting osteoclastogenesis.
Proc Natl Acad Sci USA, 111 (6): 2289-94. [PMID:24469824]

3. Komura K, Yoshizaki A, Kodera M, Iwata Y, Ogawa F, Shimizu K, Wayaku T, Yukami T, Murata M, Hasegawa M et al.. (2008)
Increased serum soluble OX40 in patients with systemic sclerosis.
J Rheumatol, 35 (12): 2359-62. [PMID:18843780]

4. Webb GJ, Hirschfield GM, Lane PJ. (2016)
OX40, OX40L and Autoimmunity: a Comprehensive Review.
Clin Rev Allergy Immunol, 50 (3): 312-32. [PMID:26215166]