IL-1α   Click here for help

GtoPdb Ligand ID: 4973

Synonyms: hematopoietin-1 | interleukin-1 alpha
Immunopharmacology Ligand
Comment: IL-1α is an IL-1 family cytokine.
Species: Human
1. Hong DS, Janku F, Naing A, Falchook GS, Piha-Paul S, Wheler JJ, Fu S, Tsimberidou AM, Stecher M, Mohanty P et al.. (2015)
Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer.
Invest New Drugs, 33 (3): 621-31. [PMID:25822109]
2. Lacy SE, Wu C, Ambrosi DJ, Hsieh CM, Bose S, Miller R, Conlon DM, Tarcsa E, Chari R, Ghayur T et al.. (2015)
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1β.
MAbs, 7 (3): 605-19. [PMID:25764208]
3. Simard J. (2009)
Interleukin-1 alpha abs and methods of use.
Patent number: WO2009148575 A1. Assignee: Xbiotech, Inc.. Priority date: 30/05/2008. Publication date: 10/12/2009.