G-CSF

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Ligands
G-CSF (Human)

GtoPdb Ligand ID: 4934

Synonyms: Granocyte®

G-CSF is an approved drug

Compound class: Endogenous peptide in human, mouse or rat

Comment: Lenograstim is a recombinant form of glycosylated granulocyte colony-stimulating factor, with exactly the same sequence and function as the endogenous peptide.

Species: Human

References
1. Amadori S, Suciu S, Jehn U, Stasi R, Thomas X, Marie JP, Muus P, Lefrère F, Berneman Z, Fillet G et al.. (2005) Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study. Blood, 106 (1): 27-34. [PMID:15761020]
2. Jurcevic S, Humfrey C, Uddin M, Warrington S, Larsson B, Keen C. (2015) The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions. Br J Clin Pharmacol, 80 (6): 1324-36. [PMID:26182832]
3. Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F, Groth E, Larsson B, Böttcher G, Malmgren A et al.. (2017) Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma. Pulm Pharmacol Ther, 45: 121-123. [PMID:28549850]

References

1. Amadori S, Suciu S, Jehn U, Stasi R, Thomas X, Marie JP, Muus P, Lefrère F, Berneman Z, Fillet G et al.. (2005)
Use of glycosylated recombinant human G-CSF (lenograstim) during and/or after induction chemotherapy in patients 61 years of age and older with acute myeloid leukemia: final results of AML-13, a randomized phase-3 study.
Blood, 106 (1): 27-34. [PMID:15761020]

2. Jurcevic S, Humfrey C, Uddin M, Warrington S, Larsson B, Keen C. (2015)
The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions.
Br J Clin Pharmacol, 80 (6): 1324-36. [PMID:26182832]

3. Watz H, Uddin M, Pedersen F, Kirsten A, Goldmann T, Stellmacher F, Groth E, Larsson B, Böttcher G, Malmgren A et al.. (2017)
Effects of the CXCR2 antagonist AZD5069 on lung neutrophil recruitment in asthma.
Pulm Pharmacol Ther, 45: 121-123. [PMID:28549850]