thrombin   Click here for help

GtoPdb Ligand ID: 4453

Compound class: Endogenous peptide in human, mouse or rat
Comment: Thrombin is a serine protease that acts as an agonist at the protease-activated GPCR family. Active thrombin is a complex between thrombin light chain and thrombin heavy chain. The chains are linked by a disulphide bond between cysteine residues at position 9 of the light chain and 118 of the heavy chain.
Species: Human

This ligand is also described as a target entry: coagulation factor II, thrombin

References
1. Austin KM, Covic L, Kuliopulos A. (2013)
Matrix metalloproteases and PAR1 activation.
Blood, 121 (3): 431-9. [PMID:23086754]