M32   Click here for help

GtoPdb Ligand ID: 3897

Synonyms: galanin(1-13)neuropeptide Y-amide(25-36)amide
Compound class: Peptide or derivative
Comment: A synthetic chimeric peptide, consisting of galanin (1-13) and neuropeptide Y (25-36)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Borowsky B, Walker MW, Huang LY, Jones KA, Smith KE, Bard J, Branchek TA, Gerald C. (1998)
Cloning and characterization of the human galanin GALR2 receptor.
Peptides, 19 (10): 1771-81. [PMID:9880084]
2. Fathi Z, Battaglino PM, Iben LG, Li H, Baker E, Zhang D, McGovern R, Mahle CD, Sutherland GR, Iismaa TP et al.. (1998)
Molecular characterization, pharmacological properties and chromosomal localization of the human GALR2 galanin receptor.
Brain Res Mol Brain Res, 58 (1-2): 156-69. [PMID:9685625]
3. Saar K, Mahlapuu R, Laidmäe E, Valkna A, Kahl U, Karelson E, Langel U. (2001)
Characterisation of a new chimeric ligand for galanin receptors: galanin(1-13)-[D-Trp(32)]-neuropeptide Y(25-36)amide.
Regul Pept, 102 (1): 15-9. [PMID:11600206]
4. Smith KE, Forray C, Walker MW, Jones KA, Tamm JA, Bard J, Branchek TA, Linemeyer DL, Gerald C. (1997)
Expression cloning of a rat hypothalamic galanin receptor coupled to phosphoinositide turnover.
J Biol Chem, 272 (39): 24612-6. [PMID:9305929]
5. Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao WJ, Vaysse PJ, Branchek TA, Gerald C et al.. (1998)
Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels.
J Biol Chem, 273 (36): 23321-6. [PMID:9722565]