C3a   Click here for help

GtoPdb Ligand ID: 3640

Synonyms: C3a anaphylatoxin | C3a anaphylatoxin polypeptide | complement component C3a
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Ames RS, Nuthulaganti P, Kumar C. (1996)
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.
FEBS Lett, 395 (2-3): 157-9. [PMID:8898085]
2. Ames RS, Tornetta MA, Foley JJ, Hugli TE, Sarau HM. (1997)
Evidence that the receptor for C4a is distinct from the C3a receptor.
Immunopharmacology, 38 (1-2): 87-92. [PMID:9476119]
3. Scully CC, Blakeney JS, Singh R, Hoang HN, Abbenante G, Reid RC, Fairlie DP. (2010)
Selective hexapeptide agonists and antagonists for human complement C3a receptor.
J Med Chem, 53 (13): 4938-48. [PMID:20527893]