ATX-II   Click here for help

GtoPdb Ligand ID: 2614

Synonyms: anemonia viridis toxin 2 | Sea anemone toxin II (Anemonia sulcata) | toxin ATX-II
Compound class: Peptide or derivative
Comment: From Anemonia sulcata (Mediterranean snakelocks sea anemone)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Chahine M, Plante E, Kallen RG. (1996)
Sea anemone toxin (ATX II) modulation of heart and skeletal muscle sodium channel alpha-subunits expressed in tsA201 cells.
J Membr Biol, 152 (1): 39-48. [PMID:8660409]
2. Oliveira JS, Redaelli E, Zaharenko AJ, Cassulini RR, Konno K, Pimenta DC, Freitas JC, Clare JJ, Wanke E. (2004)
Binding specificity of sea anemone toxins to Nav 1.1-1.6 sodium channels: unexpected contributions from differences in the IV/S3-S4 outer loop.
J Biol Chem, 279 (32): 33323-35. [PMID:15169781]