arvanil   Click here for help

GtoPdb Ligand ID: 2485

Synonyms: N-vanillylarachidonamide
Compound class: Synthetic organic
Comment: Arvanil is a synthetic endocannabinoid-vanilloid hybrid molecule [2], with agonist action at transient receptor potential vanilloid 1 (TRPV1) channels and cannabinoid 1 (CB1) receptors [3-5].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 18
Topological polar surface area 58.56
Molecular weight 439.31
XLogP 9.09
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCc1ccc(c(c1)OC)O
Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCc1ccc(c(c1)OC)O
InChI InChI=1S/C28H41NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-28(31)29-24-25-21-22-26(30)27(23-25)32-2/h7-8,10-11,13-14,16-17,21-23,30H,3-6,9,12,15,18-20,24H2,1-2H3,(H,29,31)/b8-7-,11-10-,14-13-,17-16-
InChI Key QVLMCRFQGHWOPM-ZKWNWVNESA-N
References
1. Correll CC, Phelps PT, Anthes JC, Umland S, Greenfeder S. (2004)
Cloning and pharmacological characterization of mouse TRPV1.
Neurosci Lett, 370 (1): 55-60. [PMID:15489017]
2. de Lago E, Urbani P, Ramos JA, Di Marzo V, Fernández-Ruiz J. (2005)
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.
Brain Res, 1050 (1-2): 210-6. [PMID:15975564]
3. Melck D, Bisogno T, De Petrocellis L, Chuang H, Julius D, Bifulco M, Di Marzo V. (1999)
Unsaturated long-chain N-acyl-vanillyl-amides (N-AVAMs): vanilloid receptor ligands that inhibit anandamide-facilitated transport and bind to CB1 cannabinoid receptors.
Biochem Biophys Res Commun, 262 (1): 275-84. [PMID:10448105]
4. Oz M. (2006)
Receptor-independent actions of cannabinoids on cell membranes: focus on endocannabinoids.
Pharmacol Ther, 111 (1): 114-44. [PMID:16584786]
5. Van Der Stelt M, Di Marzo V. (2004)
Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels.
Eur J Biochem, 271 (10): 1827-34. [PMID:15128293]