tertiapin-Q   Click here for help

GtoPdb Ligand ID: 2383

Synonyms: TPN(Q)
Compound class: Peptide or derivative
Comment: From the venom gland of Apis mellifera (honeybee)
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Felix JP, Liu J, Schmalhofer WA, Bailey T, Bednarek MA, Kinkel S, Weinglass AB, Kohler M, Kaczorowski GJ, Priest BT, Garcia ML. (2006)
Characterization of Kir1.1 channels with the use of a radiolabeled derivative of tertiapin.
Biochemistry, 45 (33): 10129-39. [PMID:16906771]
2. Jin W, Klem AM, Lewis JH, Lu Z. (1999)
Mechanisms of inward-rectifier K+ channel inhibition by tertiapin-Q.
Biochemistry, 38 (43): 14294-301. [PMID:10572004]
3. Jin W, Lu Z. (1998)
A novel high-affinity inhibitor for inward-rectifier K+ channels.
Biochemistry, 37 (38): 13291-9. [PMID:9748337]
4. Jin W, Lu Z. (1999)
Synthesis of a stable form of tertiapin: a high-affinity inhibitor for inward-rectifier K+ channels.
Biochemistry, 38 (43): 14286-93. [PMID:10572003]