neuromedin U-25   Click here for help

GtoPdb Ligand ID: 1470

Abbreviated name: NmU-25
Synonyms: human neuromedin U-25 | NMU-25
Compound class: Endogenous peptide in human, mouse or rat
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Aiyar N, Disa J, Foley JJ, Buckley PT, Wixted WE, Pullen M, Shabon U, Dul E, Szekeres PG, Elshourbagy NA et al.. (2004)
Radioligand binding and functional characterization of recombinant human NmU1 and NmU2 receptors stably expressed in clonal human embryonic kidney-293 cells.
Pharmacology, 72 (1): 33-41. [PMID:15292653]
2. Brighton PJ, Szekeres PG, Wise A, Willars GB. (2004)
Signaling and ligand binding by recombinant neuromedin U receptors: evidence for dual coupling to Galphaq/11 and Galphai and an irreversible ligand-receptor interaction.
Mol Pharmacol, 66 (6): 1544-56. [PMID:15331768]
3. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams Jr DL, Feighner SD, Nunes CN et al.. (2000)
Identification of receptors for neuromedin U and its role in feeding.
Nature, 406 (6791): 70-4. [PMID:10894543]
4. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS et al.. (2000)
Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system.
J Biol Chem, 275 (42): 32452-9. [PMID:10899166]