inbakicept

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Ligands
inbakicept

GtoPdb Ligand ID: 11593

Synonyms: 15RalphaSu-Fc

Compound class: Peptide or derivative

Comment: Inbakicept is a fusion protein that links the Sushi domain of the IL15 receptor α subunit (amino acids 1-65 of the peptide sequence provided here) with a human IgG1 Fc domain (aa 81-190 Fc CH2 domain, aa 191-297 Fc CH3 domain). It is one of the protein components of the clinical stage IL-15 superagonist complex ALT-803 [1-2]. It forms a dimeric structure that binds nogapendekin alfa.

References
1. Kim PS, Kwilas AR, Xu W, Alter S, Jeng EK, Wong HC, Schlom J, Hodge JW. (2016) IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas. Oncotarget, 7 (13): 16130-45. [PMID:26910920]
2. Xu W, Jones M, Liu B, Zhu X, Johnson CB, Edwards AC, Kong L, Jeng EK, Han K, Marcus WD et al.. (2013) Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Res, 73 (10): 3075-86. [PMID:23644531]

References

1. Kim PS, Kwilas AR, Xu W, Alter S, Jeng EK, Wong HC, Schlom J, Hodge JW. (2016)
IL-15 superagonist/IL-15RαSushi-Fc fusion complex (IL-15SA/IL-15RαSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas.
Oncotarget, 7 (13): 16130-45. [PMID:26910920]

2. Xu W, Jones M, Liu B, Zhu X, Johnson CB, Edwards AC, Kong L, Jeng EK, Han K, Marcus WD et al.. (2013)
Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor αSu/Fc fusion complex in syngeneic murine models of multiple myeloma.
Cancer Res, 73 (10): 3075-86. [PMID:23644531]